Results 191 to 200 of about 53,587 (267)

Morphology-Aware Peptide Discovery via Masked Conditional Generative Modeling. [PDF]

ACS Nano
Costa N, Zavadlav J.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Enhanced Representation-Based Sampling for the Efficient Generation of Data Sets for Machine-Learned Interatomic Potentials. [PDF]

J Chem Theory Comput
Schäfer MR, Kästner J.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Physics-Guided Machine Learning for Performance Prediction and Multi-Objective Optimization of High-Conductivity Aluminum Conductors. [PDF]

Materials (Basel)
Miao Y, Cao Z, Yao T, Wang Y, Gao H, Wang J, Sun B.   +6 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Cut-SOAP: A Machine Learning Descriptor for Rapid Screening of Molecular Adsorption Energetics. [PDF]

ACS Omega
Calderan FV, Andriani KF, Felício-Sousa P, Pinheiro GA, Da Silva JLF, Quiles MG.   +5 more
europepmc   +1 more source

Explainable Artificial Intelligence (xAI) for 5-HT_2A Receptor Binding Affinity of New Psychoactive Substances. [PDF]

Molecules
Schöning V, Grafinger KE, Pasin D, Stove CP, Weinmann W, Hammann F.   +5 more
europepmc   +1 more source

The Tsetlin Machine: A "Third Way" in QSAR Modeling. [PDF]

J Chem Inf Model
Clarke PFA, Cmelo I, Helin R, Shende MK, Granmo OC, Fayne D.   +5 more
europepmc   +1 more source

Pocket-Surface Discrete Differential Geometry as a Leakage-Robust Feature Class for Protein-Ligand Binding Affinity Prediction. [PDF]

Molecules
Balcı MA, Çetin E, Calibasi-Kocal G, Akgüller Ö.   +3 more
europepmc   +1 more source