Results 181 to 190 of about 139,829 (218)

Mapping the Chemical Space of Synthetic and Natural Product Chelators. [PDF]

ACS Omega
Feeney SV, Matthews ST, Codd R.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Computed Tomographic Lesion Descriptors in Foals With Hematogenous Osteomyelitis: Interobserver Agreement and Association With Outcome. [PDF]

Vet Radiol Ultrasound
Gustafsson K, Longo M, Vanderperren K, Haardt H, Haspeslagh M, Stas E, De Zani D, Buyck C, Robert M, Zani DD.   +9 more
europepmc   +1 more source

Non-equilibrium crystallization and spatial fingerprints in flash IR-annealed halide perovskite films.

Mater Horiz
Vaccarelli O, Caldara TA, Gisler C, Hennebert J, Alonso SS.   +4 more
europepmc   +1 more source

Design of Thermotropic Liquid Crystal Molecules With a Wide Temperature Range for the Liquid Crystal Phase Using Machine Learning. [PDF]

Mol Inform
Masuyama N, Kaneko H.
europepmc   +1 more source

DA-MoE: descriptor-attention mixture-of-experts for multi-class gastrointestinal disease classification. [PDF]

Front Oncol
Xu Y, Liu L, Tang M.
europepmc   +1 more source