Results 221 to 230 of about 405,178 (360)

Machine Learning-Driven QSAR Modeling for pK_a Prediction of Ionizable Lipids in Lipid Nanoparticles for Hepatic Gene Silencing. [PDF]

Int J Mol Sci
Kongtaworn N, Toopradab B, Todsaporn D, Tinpovong P, Thongsuebsaeng R, Maitarad P, Rungrotmongkol T.   +6 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Learning local feature descriptors with triplets and shallow convolutional neural networks

British Machine Vision Conference, 2016
Vassileios Balntas, Edgar Riba, D. Ponsa, K. Mikolajczyk   +3 more
semanticscholar   +1 more source

Editorial: Design of extended networks for tuning functionality of materials. [PDF]

Front Chem
Alexandrov EV, Kuznetsov AE, Li Y.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

High-Efficiency Prediction of Surfactant Properties through Automated Hydrophilic-Hydrophobic Partitioning. [PDF]

J Chem Inf Model
González-Núñez S, Amador C, Martín M.   +2 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Overview of AI-Based Scent Creation. [PDF]

Sensors (Basel)
Nakamoto T, Aleixandre M.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Integration of 2D and 3D Imaging Descriptors with Large Language Models for Assessing Pediatric Foreign-Body Aspiration Risk. [PDF]

Children (Basel)
Gregori D, Papappicco CAM, Vucinic D, Giraudo C, Ibrisevic A, Harcinovic A, Umihanić Š, Brkic F, Baldas S, Lorenzoni G, Ocagli H.   +10 more
europepmc   +1 more source