Results 181 to 190 of about 67,666 (216)

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Successful extracorporeal membrane oxygenation-bridged rituximab desensitization enabling blood type-incompatible living-donor lung transplantation. [PDF]

JTCVS Tech
Watanabe Y, Hirama T, Watanabe T, Oishi H, Akiba M, Mukai S, Saito M, Kumata S, Onodera K, Togo T, Notsuda H, Suzuki T, Niikawa H, Okada Y, Tohoku Lung Transplant Group.   +14 more
europepmc   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

A systematic review and meta‐analysis of school‐based interventions for PTSD and trauma‐related symptoms: what effective elements they have in common?

Child and Adolescent Mental Health, EarlyView.
Background Schools provide critical support for students exposed to traumatic experiences, with school‐based trauma interventions demonstrating reductions in posttraumatic stress symptoms. However, heterogeneity in design, implementation, and efficacy of existing interventions makes it challenging to select suitable interventions and to understand ...
Kirsten Rowlinson, Lucinda Grummitt, Isabelle Lynch, Chloe Conroy, Ivana Kihas, Erin Kelly, Emma L. Barrett   +6 more
wiley   +1 more source

Outcome of Emergent ABO-Incompatible Liver Transplantation is Acceptable but at the Cost of Higher Diffuse Intrahepatic Biliary Stricture: A Single-Center, Retrospective Study. [PDF]

Ther Clin Risk Manag
Liu J, Qi J, Chen Y, Duan X, Yu X, Jin P, Zhang Y, Zhang W.   +7 more
europepmc   +1 more source

Behaviour Support in Dentistry Core Outcomes (BeSiDe‐CO): A Core Outcome Set Development Study

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To develop a Core Outcome Set suitable for adults and children for use in studies of Dental Behaviour Support (DBS) techniques, including non‐pharmacological DBS, sedation and General Anaesthesia research. Methods Two systematic reviews generated a preliminary list of candidate outcomes that were shared with Key Stakeholders (KSG ...
Caoimhin Mac Giolla Phadraig, Isabel C. Olegário, Shaelynn Hsu, Maryam Al Zayer, Aisyah Binti Ahmad Fisal, Alison Dougall, Gareth B. Kitchen, Henry F. Duncan, Sarah Baker, Sharat Pani, Sreekanth Kumar Mallineni, Mandy Daly, The BeSiDe COS Collaboration, Tracey Scott, Carolyn Akintola, Éilish Burke, Steve Moore, Barbara Vallo, Jacobo Posse Limerese, Karin Alexandra Van Nes, Maiken Bagger, Olive Healy, Andrew Geddis‐Regan   +22 more
wiley   +1 more source

Successful rapid desensitization to multiple insulin preparations in an adult with type 1 diabetes: a case report and literature review. [PDF]

Front Endocrinol (Lausanne)
Chen Y, Zhu W, Chen G, Yao J.
europepmc   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source

Analytical Robustness and Competing Interpretations in Violent Video Game Research: A Response to Teng and Bushman's (2026) Reanalysis of Lacko et al. (2024). [PDF]

Aggress Behav
Lacko D, Machackova H, Smahel D.
europepmc   +1 more source