Results 261 to 270 of about 7,143 (329)

Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1517-1538, April 2026.
Abstract Background and Purpose Alarming trends show that vaping e‐cigarettes containing synthetic cannabinoid receptor agonists, such as JWH‐018, is increasing among youth. However, the effects of these trends are unclear in both sexes. We therefore characterized the neuropharmacological effects of adolescent JWH‐018 inhalation in male and female rats.
Nicholas Pintori   +7 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Casein Phosphopeptide and Diode Laser in Treating Dentin Hypersensitivity: A Clinical Study. [PDF]

open access: yesJ Lasers Med Sci
Faheem S   +8 more
europepmc   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

open access: yesInternational Journal of Dermatology, Volume 65, Issue 4, Page 706-723, April 2026.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska   +8 more
wiley   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek   +7 more
wiley   +1 more source

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath   +5 more
wiley   +1 more source

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