Results 11 to 20 of about 519,025 (217)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Regional institutions in recent Argentina: the dilemma of public policy on regional development [PDF]

open access: yes, 2013
La estrategia de desarrollo regional argentina promueve la institucionalidad regional como intermediaria entre la política pública y sus destinatarios.
Fernández, Víctor Ramiro   +2 more
core   +3 more sources

AGROTURISMO E DESENVOLVIMENTO REGIONAL

open access: yesGeo UERJ, 2020
O LIVRO DE ANDERSON PORTUGUEZ, QUE AQUI COMENTAMOS, É FRUTO DE SUA DISSERTAÇÃO DE MESTRADO EM GEOGRAFIA HUMANA NA USP E VERSA SOBRE TURISMO EM ESPAÇO RURAL NO ESPÍRITO SANTO. O LIVRO ENCERRA UM CONTEÚDO BEM CONSISTENTE, O QUE PROVAVELMENTE É REFLEXO DA BUSCA DO AUTOR PELA INTEGRAÇÃO DO MAIOR NÚMERO DE ASPECTOS ACERCA DE SUA TEMÁTICA.
Natal, Caroline Beserra   +1 more
openaire   +2 more sources

A non-local perturbation of the logistic equation in IR N [PDF]

open access: yes, 2019
A logistic equation in the whole space is considered. In this problem, a non-local perturbation is included. We establish a new sub-supersolution method forgeneral nonlocal elliptic equations and, consequently, we obtain the existence ofpositive ...
Delgado Delgado, Manuel   +3 more
core  

Planejamento regional em Brasília o Fundefe e o Pergeb nas décadas de 1960 e 1970 [PDF]

open access: yes, 2013
O presente trabalho tem como objetivo investigar em que medida as ações estatais direcionadas para a estruturação regional de Brasília estiveram vinculadas aos objetivos nacionais, de desenvolvimento social e econômico, nas décadas de 1960 e 1970 ...
Faria, Rodrigo de, Freitag, Patrícia
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Desenvolvimento regional, efeito de localização e clusters agroindustriais no Brasil. [PDF]

open access: yes, 2012
Objetiva-se, neste artigo, uma breve revisão da literatura acadêmica sobre o desenvolvimento regional e o efeito de localização, buscando-se, para tanto, identificar elementos que possam estar relacionados nas diversas modalidades de organização da ...
GUIMARÃES, M. F.
core  

As companhias aéreas de baixo custo e o desenvolvimento dos destinos turísticos: um estudo de caso do aeroporto do Porto, Portugal [PDF]

open access: yes, 2018
Mobility is one of the characteristics of modern society. The world today, despite the uncertainties brought by globalization is an interconnected reality of networks, whether physical or virtual.
Almeida, Claudia, Costa, Vânia
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

open access: yesAdvanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens   +3 more
wiley   +1 more source

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