Results 211 to 220 of about 2,931,957 (285)

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Advancing Wildlife Conservation Through Biobanking in South America. [PDF]

Animals (Basel)
Madelaire CB, Pereira AF, Sestelo AJ, Bom-Conselho AP, Vaj C, Mosalve FC, Brandão-Souza LS, Tavares MR, Rodriguez MD, Restrepo RO, Leite RF, Locatelli Y, Deco-Souza T, Araujo GR.   +13 more
europepmc   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

How climate change and deforestation interact in the transformation of the Amazon rainforest. [PDF]

Nat Commun
Franco MA, Rizzo LV, Teixeira MJ, Artaxo P, Azevedo T, Lelieveld J, Nobre CA, Pöhlker C, Pöschl U, Shimbo J, Xu X, Machado LAT.   +11 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project. [PDF]

Eur J Nutr
Santucci C, Natale A, Pelucchi C, Bonzi R, Lunet N, Morais S, Vioque J, González-Palacios S, Aragonés N, Castaño-Vinyals G, Malekzadeh R, Pakseresht M, Negri E, Boffetta P, Camargo MC, Curado MP, Zhang ZF, Boccia S, La Vecchia C, Rossi M.   +19 more
europepmc   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Nursing and the essential public health functions framework in the Americas: reflections and perspectives. [PDF]

Rev Bras Enferm
Souza ENDC, Almeida ML, Conejero JES, Peres AM.   +3 more
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Mapping the density of giant trees in the Amazon. [PDF]

New Phytol
de Lima RB, da Silva DAS, Nunes MH, Bittencourt PRL, Groenendyk P, de Oliveira CP, Granato-Souza D, Caraciolo Ferreira RL, Aleixo da Silva JA, Aguirre-Gutiérrez J, Jackson T, de Matos Filho JR, Aparício PDS, da Silva JPG, de Toledo JJ, Guedes MC, de Almeida DRA, Higuchi N, Wagner FH, Ometto JP, Görgens EB.   +20 more
europepmc   +1 more source