Results 241 to 250 of about 527,991 (295)

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Bioindicators of Plastic Pollution: Insights into the Relationship between Environmental Plastic Abundance and Ingestion by Green Turtles (<i>Chelonia mydas</i>). [PDF]

Environ Sci Technol
Santos RG, Vasconcelos AC, de Oliveira PM, de Almeida JPFA, Silva I, de Oliveira BSSP, Savoca MS, Demetrio GR.   +7 more
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Foundational principles for young intensivists to drive better outcomes: the bedside application of physiology. [PDF]

Crit Care Sci
Rocco PRM, Park M, Bakker J.
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Tracking control of air flow based on a fractional-order model of the lung impedance. [PDF]

Sci Rep
Kuzminskas H, Teixeira MCM, Galvão RKH, Assunção E, Hadjiloucas S.   +4 more
europepmc   +1 more source

Is Obesity Associated With Dental Caries in Primary Dentition? Findings From a Birth Cohort in Southern Brazil

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives Nutritional disorders and dental caries share common risk factors, including diet and socioeconomic position, but the association between these two conditions remains unclear. The aim of this study was to investigate the potential association between overweight/obesity and the occurrence of dental caries in primary dentition ...
Yorrana Martins Corrêa, Cinthia Fonseca Araujo, Mariana Silveira Echeverria, Andréa Dâmaso Bertoldi, Geert J. M. G. van der Heijden, Flávio Fernando Demarco, Helena Silveira Schuch   +6 more
wiley   +1 more source

Graphene Oxide and Conductive Polymer-Enhanced Langmuir-Blodgett Biosensor for Sensitive Detection of Pyrocatechol. [PDF]

ACS Omega
Marinho FM, Salvo-Comino C, Rodriguez-Mendez ML, Siqueira Junior JR, Caseli L.   +4 more
europepmc   +1 more source