Results 191 to 200 of about 13,592 (303)

Optimizing Patient Registries for Regulatory Decision Making ‐ Key Learnings From an HMA/EMA Multistakeholder Workshop

Clinical Pharmacology &Therapeutics, EarlyView.
The Joint Heads of Medicines Agencies and European Medicines Agency's (HMA/EMA) big data initiative paves the way for better integration of real‐world data, including data from patient registries, into regulatory decisions on medicines. This article focuses on the outcome of a two‐day multistakeholder workshop organized by EMA in 2024, which explored ...
Kelly Plueschke, Carla Jonker, Hanna Kankanen, Thorsten Vetter, Bruno Sepodes, Lutz Naehrlich, Jan Hillert, Gracy Crane, Sabine Straus, Paolo Foggi, Simona Martin, Christina Kyriakopoulou, Peter Mol, Francesca Day, Kieran Breen, Neil Bennett, Mencia de Lemus Belmonte, Simon Bennett, Patrice Verpillat, Kit C. B. Roes, Ana Cochino, Franz Schaefer, Jesús María Hernández‐Rivas, Patricia McGettigan, Peter Arlett   +24 more
wiley   +1 more source

Do no Significant Harm (DNSH) Principle in Corporate Sustainability Strategies: Towards a Methodological Framework

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The integration of corporate sustainability strategies into business activities has become increasingly essential due to the growing concerns about environmental degradation resulting from population growth and resource depletion. Corporate Social Responsibility (CSR) emphasizes the need for businesses to consider their environmental and ...
Roberto Cerchione, Renato Passaro, Viviana Sicardi   +2 more
wiley   +1 more source

Probabilistic model predicts dynamics of vegetation biomass in a desert ecosystem in NW China. [PDF]

Proc Natl Acad Sci U S A, 2017
Wang XP, Schaffer BE, Yang Z, Rodriguez-Iturbe I.   +3 more
europepmc   +1 more source

Internet of Things (IoT) and the Environmental Sustainability: A Literature Review and Recommendations for Future Research

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT As the Internet of Things (IoT) surges forward, intersecting with an urgent demand for environmental sustainability (ES), digital technologies emerge as potent orchestrators of systemic transformation. Employing a subtle blend of bibliometric‐systematic literature review (B‐SLR) and qualitative insights, this research investigates IoT's ...
Giuseppe Lanfranchi, Antonio Crupi, Fabrizio Cesaroni   +2 more
wiley   +1 more source

Wetlands as environments of early human occupation: A new classification for freshwater palaeowetlands

The Depositional Record, EarlyView.
A new classification for inland freshwater palaeowetlands to be used in the field or core laboratory by sedimentologists, providing examples from the Guadix Basin (southern Spain). Abstract Present wetlands have proven to be delicate, biodiverse ecosystems, that are natural sinks for CO2 and act as good indicators for climate changes.
S. Pla‐Pueyo, E. H. Gierlowski‐Kordesch   +1 more
wiley   +1 more source

Microbialite cathodoluminescence: A tool for investigating palaeoredox conditions, alteration histories and primary textures across time

The Depositional Record, EarlyView.
Microbialites are common throughout the rock record and key to our understanding of Earth history, yet a relatively common microscopy technique—cathodoluminescence (CL)—has not previously been leveraged to understand them. In this contribution, we examine microbialites of varying ages (modern to Proterozoic) with CL and report on the patterns and ...
Cedric J. Hagen, Brianna Hibner, Juliana Olsen‐Valdez, Haley Brumberger, Catherine G. Fontana, James R. Gutoski, Jessica C. Hankins, Srishti Kashyap, Tyler A. Lincoln, Nicole Mizrahi, Kathryn E. Snell, Elizabeth J. Trower   +11 more
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Genesis and reservoir preservation mechanism of 10 000‐m ultradeep dolomite in Chinese craton basin

Deep Underground Science and Engineering, EarlyView.
Potential exploration target stratum of 10 000‐m ultradeep dolomite in Sichuan Basin and Tarim Basin, China. Abstract The 10 000‐m ultradeep dolomite reservoir holds significant potential as a successor field for future oil and gas exploration in China's marine craton basin.
Guangyou Zhu, Xi Li, Bin Zhao, Hua Jiang, Yinghui Cao, Yan Zhang, Weiyan Chen, Tingting Li, Jiakai Hou   +8 more
wiley   +1 more source

Damage modeling of CO2 injection well interfaces under coupled thermal, hydraulic and mechanical behavior

Deep Underground Science and Engineering, EarlyView.
This paper presents an investigation of CO2 injection well damage evolution considering different injection temperatures and the presence of a pre‐existing defect. The main outcome is that the accurate prediction of well leakage risk requires characteristics such as initial defects to be understood and represented in any modeling efforts. Abstract This
Lee J. Hosking, Xiangming Zhou
wiley   +1 more source

The division of food space among mammalian species on biomes

Ecography, EarlyView.
Understanding how species' ecological partitioning functions across biomes is fundamental to macroecology and conservation biology. Here, we examine the global distribution of dietary strategies in terrestrial mammals, focusing on how biome specialization modulates trophic diversity and structure at a broad geographical scale.
Sara Gamboa, Sofía Galván, Mar Sobral, Manuel Hernández Fernández, Sara Varela   +4 more
wiley   +1 more source