Results 41 to 50 of about 11,094 (310)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Subsystem trade-off environmental control and life support for orbiter phase B contractor [PDF]
, 1971 Environmental control and life support subsystem for space shuttle ...
Augusti, R., Jasin, J.
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Review of Dew Point Evaporative Cooling Technology for Air Conditioning Applications
Applied Sciences, 2021 Indirect evaporative cooling has the potential to significantly improve the natural environment. It follows from a significant reduction in electricity consumption in the hot period, and hence lower operating costs for cooling systems.
Anna Pacak, William Worek
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Next-generation HVAC: Prospects for and limitations of desiccant and membrane-based dehumidification and cooling [PDF]
, 2017 Recently, next-generation HVAC technologies have gained attention as potential alternatives to the conventional vapor-compression system (VCS) for dehumidification and cooling. Previous studies have primarily focused on analyzing a specific technology or
Chen, Tianyi +4 more
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Energies, 2014 Desiccant-based air handling units can achieve reductions in greenhouse gas emissions and energy savings with respect to conventional air conditioning systems.
Giovanni Angrisani +3 more
doaj +1 more source
Solar Desiccant Cooling System for a Commercial Building in Kuwait’s Climatic Condition
Energies, 2022 The use of air conditioning in buildings to provide a comfortable environment accounts for up to 75% of the electricity consumed in Kuwait for the hot season from April through to the end of October. The widespread adoption of air conditioning systems in
Ramadas Narayanan +3 more
doaj +1 more source