Results 201 to 210 of about 4,599,474 (260)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Internet protocol television for personalized home-based health information: design-based research on a diabetes education system.

JMIR Res Protoc, 2014
Gray KM, Clarke K, Alzougool B, Hines C, Tidhar G, Frukhtman F.   +5 more
europepmc   +1 more source

Sustainable Design Reuse: Integrating Biomimicry and Parametric Thinking in Architectural Education. [PDF]

Biomimetics (Basel)
Semlali A, Tamzini S, Cazacova L.
europepmc   +1 more source

A Systematic Taxonomy of the Sunflower Optimization Algorithm: Variants, Hybridization Strategies, Applications, and Research Directions. [PDF]

Biomimetics (Basel)
Baştemur Kaya C.
europepmc   +1 more source

Developing a Virtual Reality Application for Social and Emotional Wellbeing and Cultural Determinants of Health Support With an Aboriginal Community of Sydney, New South Wales, Australia: Protocol for an Acceptability and Feasibility Study. [PDF]

JMIR Res Protoc
Garay J, Phillips S, Purdam J, Duczynski J, Azizi M, Dickson M, Carter M, Hespanhol L, Negin J, Mooney-Somers J.   +9 more
europepmc   +1 more source

Using Experience Based Co Design to Develop an AI-Powered Digital Learning Platform for Immunization in Pakistan

Ahmed W, Ali A, Kalwar M, Ummad A, Batool R, Khan T, Bashir R, Fatima D, Bhrugri A, Memon Z.   +9 more
europepmc   +1 more source

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A Review of Design-Based Research

2016 IEEE 16th International Conference on Advanced Learning Technologies (ICALT), 2016
This paper intends to offer a general introduction to Design-Based Research (DBR). Based on this purpose, the paper firstly identifies the dual goals of DBR, and then explains the role of Design in DBR along with the main procedures for conducting DBR.
Sheng-Shiang Tseng, Shih-Hsien Yang, Hui-Chin Yeh   +2 more
openaire   +2 more sources

Design-Based Research

2010
Design-based research, with the design experiment as its main practical method, can be characterised as an inter-disciplinary ‘mixed-method’ research approach conducted ‘in the field’ that serves applied as well as theory-building purposes. Substantial progress has been made over recent years in articulating the methodological and epistemological basis
openaire   +1 more source