Results 21 to 30 of about 48,022 (216)
Features of Preclinical Studies of Cell Therapy Products
Preclinical studies are one of the most important stages in the development of drugs for medical use, including cell therapy products (in accordance with the legislation of the Russian Federation — biomedical cell products). Regulatory authorities decide
E. V. Melnikova +3 more
doaj +1 more source
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga +3 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Types of tasks in the didactization of materials to trace the German in the history of Kiev
The article is devoted to the problem of didactization of linguistic and historical materials about the activities of German immigrants in the territory of Kyiv.
Svitlana M. Amelina
doaj +1 more source
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
FEATURES OF DESIGNING FISH PASSAGE AND FISH PASSAGE-SPAWNING CHANNELS AT WATERWORKS
Purpose: to present the features of methodological approaches to the development of layout and design solutions for fish passage and fish passage-spawning channels arranged as a part of low-head river waterworks. Materials and methods.
Viktor N. Shkura, Alexey V. Shevchenko
doaj +1 more source
The article deals with topical issues at the pre-investment stage of project design to justify decisions on the feasibility of further investment and the transition to the next stage of design - the development of project documentation.
Kirillova Ariadna, Gorelova Anna
doaj +1 more source
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song +10 more
wiley +1 more source

