Results 161 to 170 of about 7,828,613 (296)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Artificial intelligence-driven computational methods for antibody design and optimization. [PDF]

MAbs
Vecchietti LF, Wijaya BN, Armanuly A, Hangeldiyev B, Jung H, Lee S, Cha M, Kim HM.   +7 more
europepmc   +1 more source

A Self-recording Microphotometer of New Design [PDF]

, 1936
C. S. Beals
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Du design thinking au design fiction

Technologie et Innovation
Thomas Michaud
doaj   +1 more source

Bio-inspired acoustic metamaterials for traffic noise control: bridging the gap with machine learning. [PDF]

Commun Eng
Lu JH, Ding S, Ni YQ, Li S.
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Multi-objective optimization of daylighting performance and solar radiation for building geometry using a hybrid evolutionary algorithm. [PDF]

Sci Rep
Lou S, Luo X, Chen Z, Gao Z, Wang R, Feng L, Zhang G, Zhang Y, Zhao Y, Li B.   +9 more
europepmc   +1 more source

The Roentgen Rays in Medicine and Surgery as an Aid in Diagnosis and as a Therapeutic Agent. Designed for the Use of Practitioners and Students.

, 1902
Francis H Williams, Francis Henry Williams   +1 more
openalex   +2 more sources

DISCUSSION. PLASTIC YIELD, SHRINKAGE, AND OTHER PROBLEMS OF CONCRETE, AND THEIR EFFECT ON DESIGN. [PDF]

, 1928
M. F. Wilson, Simon Dixon, E O WILLIAMS, F. C. Lea, Hudson Jackson, R N STROYER   +5 more
openalex   +1 more source