Results 161 to 170 of about 23,284,066 (340)
Design Aspects of Positional Mooring System Based on LR FOIFL Rules [PDF]
, 2012 Floating offshore units, such as FPSOs, are subject to dynamic excitations from the environment and require to be moored to maintain position at the fix location of operation.
Prasetyawan, I. (Ika) +1 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Moscow Agglomeration: the 1st Stage of the Competition
Проект Байкал, 2012 - Strelka Institute for Media, Architecture and Design
doaj +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Material Tinkering. An inspirational approach for experiential learning and envisioning in product design education [PDF]
, 2017 Stefano Parisi +2 more
openalex +1 more source
4D Printing of Hydrogels: Innovation in Material Design and Emerging Smart Systems for Drug Delivery [PDF]
, 2022 Tuan Sang Tran +4 more
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1 [PDF]
, 2020 Carlos Sànchez‐Martìn +9 more
openalex +1 more source