Results 161 to 170 of about 15,545,883 (264)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Academic Design

, 2015
This paper proposes to reshape the discussion design schools about the relationship of design practice to research. Many universities now have very successful design departments that educate high-level design practitioners.
Dorst, CH Kees, Koskinen, IK, Koskinen, Ilpo K., Dorst, CH, Dorst, C.H.   +4 more
core  

Du design thinking au design fiction

Technologie et Innovation
Thomas Michaud
doaj   +1 more source

Co-Designing Wellbeing Initiatives With Rural Adolescents: What Works, What Doesn't, and Why. [PDF]

Health Promot J Austr
Kernot J, Kiriam S, Seekamp S, Little K, Hunt K, Lister E, Maher C, Brinsley J.   +7 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Introducing a New Research Design: The Multidimensional Interpretative Textual (MIT) Design. Epistemological and Methodological Foundations. [PDF]

Nurs Inq
Figura M, Arcadi P, Vellone E.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Engaging Service Users in Co-Designing a Nurse-Led Weight Talk Tool for Low- and Medium-Secure Mental Health Inpatient Settings: A Participatory Intervention Development Study. [PDF]

Int J Ment Health Nurs
Mak NKN, Dibb B, Stokes N, Barley EEA, Zasada M.   +4 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Geometry-Mechanics Compatibility Enables Interpretable Inverse Design of Non-Rigid Origami. [PDF]

Research (Wash D C)
Sun Y, Song K, Wang Y, Xue W, Li Y, Zhou X.   +5 more
europepmc   +1 more source