Results 221 to 230 of about 21,360,861 (309)

Co-Designing Local Collaboration Between Social Services, Primary Healthcare, and the Third Sector-A Realist Process Evaluation. [PDF]

Health Expect
Flink M, Johansson K, Lindgren C, Wallcook S, Klinga C, Meinow B, Goliath I, Strehlenert H.   +7 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

A Pre-Post Study of the Feasibility, Acceptability and Benefits of a Co-Design Approach for the Development of a Digital Suicide Prevention App for International Students. [PDF]

Health Expect
Ng C, Shaikh T, Robinson J, Nicholas J, Browne V, Chinnery G, Choi I, Nation-Ingle B, Allison K, Perlow E, Lamblin M, Brown E, Armstrong G, Mani M, McKay S.   +14 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

MxDiffusion: A Physics-Aware Maxwell's Law-Guided Diffusion Model Strategy for Inverse Photonic Metasurface Design. [PDF]

Nano Lett
Mondal S, Park T, Biswas S, Wang AX, Cai W.   +4 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

OligoN-Design: A Simple and Versatile Tool to Design Specific Probes and Primers From Large Heterogeneous Datasets. [PDF]

Mol Ecol Resour
Sandin MM, Walde M, Henry N, Forn I, Simon N, Berney C, Massana R, Richter DJ.   +7 more
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

From Co-Design to Quality Improvement: Using the Double Diamond Framework to Develop Primary Care Redesign Priorities for Hypertension Care. [PDF]

Health Expect
Patil SJ, Caron A, Roach MJ, Einstadter D, Malone S, Marbury Q, Whaley M, Sullivan C, Kimmel PJ, Rockamore M, Mundorf C, Lee K, Bolen SD.   +12 more
europepmc   +1 more source