Results 31 to 40 of about 32,054,956 (337)
, 2017 Through collaboration and teamwork, we tried to fulfill the needs of refugees coming into the country. We created a temporary society (urban plan) through the use of IKEA shelters in order to better the everyday lives of refugees who are in limbo waiting
Holmström (Industrial Design), Evatt +4 more
core +2 more sources
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
UCL (University College London) Libraries Masterplan: Masterplanning Report [PDF]
, 2008 BDP were appointed to undertake a Masterplan for the UCL Main Library and the UCL Science Library and to identify how these buildings could be re-ordered to significantly improve the quality of the library environment and to facilitate the delivery of
BDP (Building Design Partnership) +1 more
core
Latin Hypercubes and Space-filling Designs [PDF]
Handbook of Design and Analysis of Experiments, Bingham, D., Dean,
A., Morris, M., and Stufken, J. ed. 593-626, CRC Press (2015), 2022 This chapter discusses a general design approach to planning computer experiments, which seeks design points that fill a bounded design region as uniformly as possible. Such designs are broadly referred to as space-filling designs.
arxiv
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Safer clinical systems : interim report, August 2010 [PDF]
, 2010 Safer Clinical Systems is the Health Foundation’s new five year programme of work to test and demonstrate ways to improve healthcare systems and processes, to develop safer systems that improve patient safety.
Cooke, Matthew (Professor of clinical systems design) +1 more
core
Design Spaces and How Software Designers Use Them: a sampler [PDF]
In Proceedings of the 1st International Workshop on Designing
Software (Designing '24), 2024. Association for Computing Machinery, New
York, NY, USA, pp. 1-8Discussions of software design often refer to using "design spaces" to describe the spectrum of available design alternatives. This supports design thinking in many ways: to capture domain knowledge, to support a wide variety of design activity, to analyze or predict properties of alternatives, to understand interactions and dependencies among design ...
arxiv +1 more source
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source