Results 51 to 60 of about 23,284,066 (340)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Design issues and experimental characterization of a continuously-tuned adaptive CMOS LNA [PDF]

open access: yes, 2010
This paper presents the design implementation and experimental characterization of an adaptive Low Noise Amplifier (LNA) intended for multi-standard Radio Frequency (RF) wireless transceivers.
Becerra Álvarez, Edwin C.   +2 more
core  

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Boosting innovation and growth through the use of design

open access: yesJournal of Business Economics and Management, 2016
The question underpinning this study is: would the incorporation of design throughout every dimension of a company's business pursuing innovation result in higher levels of growth and competitiveness? The paper begins with a brief theoretical approach to
Pedro Picaluga Nevado   +2 more
doaj   +1 more source

UA30/1/1 Landscape Work, Classroom Building [PDF]

open access: yes, 1936
Landscape Work, Classroom Building, PWA KY-1043-R, UA30/1/1 Includes plan with details and sections for area surrounding Cherry Hall and Cedar ...
WKU Planning, Design & Construction
core   +1 more source

Sustainable design and the design curriculum [PDF]

open access: yes, 2008
This paper reports on an initial study that begins the process of considering how design education should deal with the issue of sustainable design specifically in the context of the education of graduate designers in the fields of product, design ...
Humphries-Smith, Tania
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Optimización del overrun (aireado), de la dureza, la viscosidad y los costos de un helado mediante el diseño de mezclas

open access: yesIngeniería Industrial, 2015
El presente trabajo de investigación experimental tiene como objetivo principal utilizar el diseño de mezclas para optimizar cuatro factores en estudio: el overrun (aireado), la dureza, la viscosidad y los costos de un helado de crema, para lo cual la ...
Jorge-Efraín Michue-Mango   +2 more
doaj   +1 more source

UA30/1/1 A Campus Guide for Western Kentucky State College [PDF]

open access: yes, 1949
A campus guide for Western Kentucky State College by DFH, 2 sheets measuring 8 1/2 x 11. The map shows the following buildings and features: Administration Building - Van Meter Hall Library - Gordon Wilson Hall Cherry Hall Training School Cedar House -
WKU Planning, Design & Construction
core   +1 more source

Experimental Design: Design Experimentation [PDF]

open access: yes, 2011
This paper was selected for publication in MIT’s Design Issues. The research takes an original approach by positioning experimentation as a comprehensive design methodology, rather than using the traditional industrial design approach of employing ...
Anthony J., Ashley Hall
core   +1 more source

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