Results 91 to 100 of about 636,549 (266)

Design and Construction Processes for Civic Reappropriation of Urban Voids. The Machi Hata Project in Nagano (Japan)

Dearq
This article presents an active service-learning methodology as a pedagogical approach in architecture schools, centered on the community-led appropriation of public space.
Kosuke Sakura, Ignacio Grávalos Lacambra, Patrizia Di Monte, Manuel Alejandro Rufasto Ñañez   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Resilience-Vulnerability Balance and Obstacle Factor Analysis in Urban Flooding: A Case Study in the Qinghai–Tibetan Plateau

Buildings
Under the combined influence of climate change and urban development, the risk of urban flooding caused by extreme weather events has increased significantly, making assessing flood vulnerability and resilience increasingly crucial for urban flood ...
Wenjing Wang, Chao Xu, Junchao He, Zhongwen Chi, Weilan Bai, Rui Liu   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Construction design

, 2021
The Mihouse urban project consists of common areas with buildings with four to five stories formed by groups of apartments. These buildings can be replicated depending on the place, the density requirements and the types of urban blocks. The whole residential condominium would be composed by 30 buildings surrounded by eight parks destined for different
González Zuluaga, Mariana, Muñoz Lombo, Juliana Alexandra, Aguirre, Juan Pablo, Gómez Etayo, Diego Fernando, Holguin Gonzalez, Javier Ernesto, López Castrillón, Yuri Ulianov   +5 more
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Overview on the characteristics of houseboats in the Royal Belum State Park, Perak, Malaysia

Journal of Asian Architecture and Building Engineering
In Royal Belum State Park, Perak, Malaysia, houseboats have become tourist attractions, complementing its biodiversity and natural landscape. Nevertheless, studies have yet to be carried out on houseboats in Malaysia in general or in Royal Belum State ...
Rohaslinda Ramele Ramli, Norashikin Ahmad Kamal   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Design and Construction of Enzyme-Based Electrochemical Gas Sensors. [PDF]

Molecules, 2023
Zhang W, Chen X, Xing Y, Chen J, Guo L, Huang Q, Li H, Liu H.   +7 more
europepmc   +1 more source