Results 241 to 250 of about 4,803,101 (299)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

How to Interpret the Head-Up Tilt Table Test: Teaching the 3 Core Orthostatic Hemodynamic Patterns. [PDF]

Neurol Educ
Shekhawat P, Varma-Doyle A, Farhad K, Robbins NM, Novak P.   +4 more
europepmc   +1 more source

The role of gamification in sustainable teacher education: Examining concept images of curriculum elements using a solomon four-group design. [PDF]

PLoS One
Uysal F.
europepmc   +1 more source

An Oxygenating Video Laryngoscope Blade With an Integrated Lens‑Clearing Gas Jet for Management of the Soiled Airway During Tracheal Intubation: Concept and Design Considerations. [PDF]

Cureus
Malone KT, Jarrett BL, Juergens AL, Drigalla DF.   +3 more
europepmc   +1 more source

Conceptualising the Patient Ecosystem: A Holistic Framework for Home Care. [PDF]

Scand J Caring Sci
Milavec Kapun M.
europepmc   +1 more source

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On the Design of Mathematical Concepts

2002
It is one of the deep mathematical insights that foundational systems like firstorder logic or set theory can be used to construct large parts of existing mathematics and formal reasoning. Unfortunately this insight has been used in the field of automated theorem proving as an argument to disregard the need for a diverse variety of representations ...
Manfred Kerber, Martin Pollet
openaire   +1 more source

Concept formation in design

Knowledge-Based Systems, 1998
Abstract This paper presents a computationally tractable view on where simple design concepts come from by proposing a paradigm for the formation of design concepts based on the emergence of patterns in the representation of designs. It is suggested that these design patterns form the basis of concepts.
openaire   +1 more source

Design Research as Conceptual Designing: The Manhattan Design Concept

Interacting with Computers, 2015
The term ‘conceptual designing’ refers to an activity that various practitioners already undertake, but for which we lack a clear definition. This article provides that definition and uses an example of a design concept called ‘Manhattan’ to present how exactly this type of process happens.
Jacucci, Giulio, Sellen, Abigail, Harper, Richard, Ylirisku, Salu   +4 more
openaire   +4 more sources

Metaprogetto e design concept / Brief and Design concept

2019
Il capitolo descrive il processo che può portare dall'analisi delle esigenze e della struttura dei sistemi urbani alla definizione delle destinazioni d'uso e dell'organizzazione delle attività e degli spazi, in un processo creativo e non deterministico ma ben radicato nella conoscenza del sito e delle condizioni di partenza del progetto ai diversi ...
Micono, Carlo, Per-Johan, Dahl, Pollo, Riccardo   +2 more
openaire   +1 more source