Results 51 to 60 of about 4,347,183 (334)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Application of 3D Printing Technology in Footwear Design and Manufacture – A Review of Developing Trends

Textile & Leather Review
The advent of 3D printing (3DP) has garnered significant interest from both academia and industry due to its potential to revolutionize engineering, manufacturing, and through its utilization of advanced materials.
Tong Zhan Cui, Rafiu King Raji, Jian Lin Han, Yuan Chen   +3 more
doaj   +1 more source

Composite dowels shear connectors for steel-concrete composite beams: a review [PDF]

Revista IBRACON de Estruturas e Materiais
Composite dowels are shear connectors primarily used in steel-concrete composite beams for building and prefabricated composite bridge construction. This paper aims to investigate the current state-of-the-art and contribute to the development of the ...
João Vitor Fioresi Altoé, Camila Spagnol de Faria, Mateus Couri Petrauski, Caio Lopes Pereira, José Luiz Rangel Paes, Gustavo de Souza Veríssimo   +5 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The Concept Design of Rice Quality Detection System Using Model-Based System Engineering Approach

Journal of Applied Agricultural Science and Technology
Quality of rice is determined by several factors such as water content, broken grains, and whiteness. The approach often used for the measurement is manual, time-consuming, and prone to error.
Purwa Tri Cahyana, Titi Candra Sunarti, Erliza Noor, Hartrisari Hardjomidjojo, Noer Laily   +4 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Influence of the design concept of an experimental demonstration model of a rocket design element on the process of heat and mass transfer

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение
A conceptual design of an experimental demonstration model of three-layer structure of a launch vehicle body is proposed, based on the replacement of aluminum honeycomb filler with an energy-related material, in particular, based on composite solid ...
V. I. Trushlyakov, Yu. V. Surikova, D. Yu. Davydovich   +2 more
doaj   +1 more source

Concept of Thermal Sheet and its Design for Sustainable Heating and Cooling Using Thermodynamics and Heat Transfer [PDF]

, 2016
The present disclosure relates to an apparatus that can maintain a required thermal condition[TC] of an object for a period of time. The apparatus comprises a thermal sheet[TS] having thickness[t] nearly same as a blanket and incorporates a pipe to ...
Prashar, H. (Hitesh), Q, H. S. (Husain), Rohilla, A. (Ashish), Vikal, A. (Anuj)   +3 more
core   +1 more source

A robust design methodology suitable for application to one-off products [PDF]

, 1998
Robust design is an activity of fundamental importance when designing large, complex, one-off engineering products. Work is described which is concerned with the application of the theory of design of experiments and stochastic optimization methods to ...
COATES G., LUCAS J.M., R. I. Whitfield, SALVESEN N., TAGUCHI G., WELCH W.J.   +5 more
core   +2 more sources