Results 161 to 170 of about 16,681,192 (303)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Possible Relevance of Hepatoma-derived Growth Factor and Alkylglycerone Phosphate Synthase to Pancreatic Cancer Progression. [PDF]

open access: yesIn Vivo
Enomoto H   +10 more
europepmc   +1 more source

Design Factors; Tools for Design Thinking

open access: yesDesign Factors; Tools for Design Thinking
As more and more people find themselves confronted with design issues - in the roles of planners,developers, and producers - tools which can assist communication across different domains of expertise facilitating participation in design processes and supporting evaluation as well as documentation, are required.
openaire   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

International collaborative design studio project : preparing industrial design students for the global emerging economy. Part 3

open access: yes, 2008
This paper reports on recent developments on an international collaborative industrial design studio project entering its fourth year of existence between three universities in three different countries.
Novoa, Mauricio (R13411)
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

HANDLE DIAMETER AND THE INFLUENCE ON THE ERGONOMICS OF CRUTCHES

open access: yes, 2017
The research in the field of ergonomics can contribute to the design process of Assistive Technologies using objective and subjective data measurements.
Paschoarelli, Luis Carlos [UNESP]   +11 more
core  

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