Results 131 to 140 of about 20,506,281 (310)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Active participation of people with disabilities in disaster preparedness and contingency work: A systematic literature review on methods, outcomes, and challenges

Progress in Disaster Science
Disaster risk reduction (DRR) strategies must actively include people with disabilities (PWD) to ensure equitable and effective preparedness. Although awareness of disability inclusion in DRR is growing, the literature remains fragmented, and no prior ...
Linda Stjernholm, Jonas Borell, Anna-Lisa Osvalder   +2 more
doaj   +1 more source

Acceptability of Intervention Design Factors in mHealth Intervention Research: Experimental Factorial Study. [PDF]

JMIR Mhealth Uhealth, 2021
Materia FT, Smyth JM.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Assessing Mobility of Blind and Low-Vision Individuals Through a Portable Virtual Reality System and a Comprehensive Questionnaire

IEEE Access
Blind or low-vision (BLV) individuals often have reduced independent mobility, yet new aids fails in increasing it, are not adopted enough, or both.
Johan Isaksson-Daun, Tomas Jansson, Johan Nilsson   +2 more
doaj   +1 more source

Temporal binding past the Libet clock: testing design factors for an auditory timer. [PDF]

Behav Res Methods, 2021
Muth FV, Wirth R, Kunde W.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Reflecting on four decades of progress in applying human factors engineering to medical devices

Human Factors in Healthcare, 2022
Michael E. Wiklund
doaj   +1 more source

Actualizing sustainable transport: the interplay between public policy instruments and shared mobility providers’ business models

European Transport Research Review
Cities around the world are trying to understand if and how to regulate urban mobility in a way that stimulates innovation and supports business while also promoting public values and accelerating a sustainability transition.
Erika Kriukelyte, Jana Sochor, Anna Kramers   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source