Results 121 to 130 of about 116,123 (240)

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

A Review of the Expansion and Integration of Production Line Balancing Problems: From Core Issues to System Integration. [PDF]

Sensors (Basel)
Sitahong A, Lu Z, Yuan Y, Mo P, Ma J.
europepmc   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Integration of safety and sustainability criteria into early design stages of battery cell manufacturing machinery. [PDF]

Sci Rep
Cerrillo C, Mendoza G, Ormazabal G, Popok V, Oetting H, Konersmann B, Tedeschi Gallo A, Lavigne Philippot M.   +7 more
europepmc   +1 more source

Design for Disassembly Guidelines

D 7.4 is the final outcome from Task 7.4, is an input to the policy activities in WP 8.
openaire   +1 more source

Redox‐Programmed Activation of a Dual‐Modal Probe for High‐Fidelity Tumor Delineation and Image‐Guided Surgery

Advanced Science, EarlyView.
This study presents a glutathione (GSH)‐activatable dual‐modality probe (GAP9) with a redox‐tuned activation window for precise tumor detection. It remains quenched (“OFF”) in normal tissue yet activates specifically in tumors for T1‐weighted magnetic resonance imaging (MRI) preoperative mapping and near‐infrared II (NIR‐II) fluorescence intraoperative
Haohao Yan, Yanbin Feng, Qian Jia, Ruili Zhang, Zhongliang Wang   +4 more
wiley   +1 more source

Actin Takes the Steering Wheel: A New Mitotic Safeguard in the Early Embryo. [PDF]

Research (Wash D C)
Zhang Y, Zhu S, Wang F.
europepmc   +1 more source

Ce‐Doped Lignin‐Based Nanozyme with Heat‐Activated Hydrolase Activity

Advanced Science, EarlyView.
A novel Ce‐doped lignin‐based hydrolase nanozyme (Ce‐AL) is synthesized using Ce ions coordinated with aminated industrial lignin. The Ce‐AL effectively hydrolyzes phosphate ester bonds and protein amide bonds, maintain high activity at 100°C, and successfully fights bacteria biofilms.
Xin Liu, Lijun Li, Xue Zhang, Alireza Ashori, Fubao Sun, Feng Xu, Xueming Zhang, Yao Chen   +7 more
wiley   +1 more source

Dynamic Self-Assembly and Stimuli-Responsive Disassembly of Bioactive-Loaded Cubosomes in Biomimetic Media Traced by Real-Time Small-Angle X-ray Scattering and Cryogenic Transmission Electron Microscopy. [PDF]

ACS Appl Mater Interfaces
Madrid RRM, Angelova A, Angelov B, Manna G, Mathews PD, Mertins O.   +5 more
europepmc   +1 more source

Design for Disassembly analysis

Report on analysis of Design for Disassembly and adaptability best practices. (Task 2.1).
openaire   +1 more source