Results 41 to 50 of about 116,123 (240)

Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles [PDF]

, 2012
One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from nanoparticles for maximum efficacy is ...
Alabi, Christopher A., Anderson, Daniel Griffith, Langer, Robert S, Sahay, Gaurav   +3 more
core   +1 more source

Disassemblability evaluation methods for supporting easy disassembly design

Transactions of the JSME (in Japanese)
This paper advocates promoting not only for material recycling through destructive dismantling but also for encouraging part and component reuse by disassembly to establish an environmentally friendly circular economy. Addressing the challenge of high disassembly costs impeding economic efficiency, an evaluation method considering economic feasibility ...
Ryohei TSURUTA, Shiki IWASE, Yoshimasa KUWANO, Yasuo ASAGA, Hidekazu NISHIGAKI   +4 more
openaire   +2 more sources

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

Design for Disassembly

Tehnički vjesnik = Technical gazette, 1999
It is a fact that the products of today are not designed for easy dismantling or disassembly. Integrated design, certain fastening and assembly principles and surface coatings, for example, can make it very difficult to disassemble the product and to separate materials into non contaminated groups.
openaire   +2 more sources

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Deployable Arches Based on Regular Polygon Geometry [PDF]

, 2017
This paper discusses a deployable-arch-structure design that is built using articulated bars, commonly called a scissor-system, and is based on the regular polygon geometry.
Peña Villamil, Diana Maritza, Torres Londoño, Natalia Paola   +1 more
core   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

An investigation into standards in sustainable design and manufacture [PDF]

, 2009
This paper reports upon the application of standards to reduce the negative environmental impacts of manufacturing through product lifecycle planning and closed loop production. By eliminating waste and retaining the energy embodied within materials and
Griffiths, BJ, Harrison, DJ, Lam, B, Plant, AVC   +3 more
core  

Design for Disassembly: An analytical method for assessing target components for remanufacturing

Cleaner Production Letters
The transition to a circular economy requires products to be designed for recovery, reuse, and remanufacturing. Fastening systems and product architecture play a decisive role in enabling these strategies, yet practical methods for assessing design-for-disassembly (DfD) remain limited, partically at the component level.
Sofie Bach Hybel, Emilie Folkmann, Lykke Margot Ricard   +2 more
openaire   +2 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source