Results 81 to 90 of about 50,917 (217)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Deconstruction of a prefabricated concrete building designed for disassembly–cost comparison of deconstruction and demolition

Environmental Research: Infrastructure and Sustainability
Design for disassembly (DfD) is a suggested concept for enhancing circular economy in the construction sector. To expand the usage of the DfD concept, and especially promote the markets for DfD components, more detailed cost analysis is required of each ...
Pyry Harsunen, Ulrika Uotila, Tuomo Joensuu, Arto Saari   +3 more
doaj   +1 more source

Systematic review of data modelling methods for system-level disassembly planning and control

International Journal of Sustainable Engineering
Disassembly is crucial in recovering end-of-life products in a circular economy, e.g. before remanufacturing or recycling. Research addresses the challenges of complexity and uncertainty in disassembly planning and control with data-driven approaches ...
Lasse Streibel, Finn-Augustin Brunnenkant, Nora Reinbold, Niklas Lindholm, Patrick Jordan, German Bluvstein, Michael F. Zaeh, Christina Reuter   +7 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Sustainable Packaging User-centered Design Employing CycleGAN and Deep Learning

BioResources
An innovative approach was pursued for sustainable packaging design using Cycle Generative Adversarial Networks (CycleGANs), tailored for wood packaging engraving.
Weiwei Jin, Weiye Chen, Ke Ma
doaj  

Design for Disassembly Strategies in Panelized Light Timber Framing: Analysis of Solutions Through Reuse and Recycling Potential Indices

Buildings
Design for Disassembly (DfD) is often assessed theoretically, with limited empirical evaluation of operational effort at the component level. This paper proposes an empirical assessment framework to evaluate DfD strategies in panelized light timber ...
Valentina Torres, Guillermo Íñiguez-González, Pierre Blanchet, Catalina Miranda   +3 more
doaj   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Ecodesign Strategies for Battery Enclosures: A Design-Driven Approach to Modularity, Single-Materiality and Circularity

Designs
The environmental impact of battery systems is strongly influenced by early design decisions related to materials, structural architecture and assembly strategies.
Antoni Lara, Albert Cruz, Sylvia Andrea Cruz, Magnus Carl Fredrik Eriksson, Antonio Confalonieri, Andreu Sanz   +5 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source