Results 131 to 140 of about 81,255 (346)

The ergonomics and design of an inclusive best-fit solution to workbenches

open access: yes, 2004
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In a time when the developed world, is trying to reduce the human and economic costs of musculo-skeletal disorders (MSDs), any contribution to such an ...
Gaughran, William F
core  

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

open access: yesAdvanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan   +8 more
wiley   +1 more source

Recruiting the world’s first disabled astronaut doesn’t mean space travel is inclusive [PDF]

open access: yes
This article is republished from The Conversation under a Creative Commons license. Image rights: Esa astronaut John McFall undergoes microgravity training. Esa / Novespace, Author provided (* no reuse *); The New Shepard vehicle carries paying customers
Merdin-Uygur, E, Garaj, V, Cullen, S
core  

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

open access: yesAdvanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal   +5 more
wiley   +1 more source

Sociomateriality and disabled individuals’ identity work: a critical poststructuralist research agenda

open access: yes, 2013
This paper responds to calls to rebalance the role of materiality in identity work. Taking a critical poststructuralist approach to identity work and a relational ontology perspective on sociomateriality, we explore how a ‘disabled’ person’s identity ...
Meindel, Jennifer   +2 more
core  

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

open access: yesAdvanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian   +9 more
wiley   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

open access: yesAdvanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang   +10 more
wiley   +1 more source

Sodium Ascorbate‐Accelerated Gelling Hydrogels With Rapid Self‐Mineralized Capacity for Chronic Wounds

open access: yesAdvanced Science, EarlyView.
An immunoregulatory hydrogel based on sodium ascorbate (SA)‐accelerated gelation and in situ self‐mineralization is prepared here. Such a hydrogel is constructed by mixing benzaldehyde‐ and cyanoacetate‐functionalized dextran with silver nitrate (AgNO3) and SA, enabling the ultrafast solidification and in situ self‐mineralization of silver ...
Xiaoya Ding   +4 more
wiley   +1 more source

The effectiveness of assessment instruments in measuring change in persons with an intellectual disability who have sexually offended

open access: yes, 2010
The present research was designed to examine a set of assessment measures for their effectiveness in evaluating risk and treatment needs in a small sample of intellectually disabled sex offenders (IDSOs).
Burrett, Vanessa Mary
core  

Creative Interactive Play for Disabled Children

open access: yes, 2009
The workshop addresses the emerging field of research on robotics, assistive technologies and interaction design promoting play for physically, visually, and hearing impaired children and for emotionally and mentally handicapped children. Interactive
Pollini A.   +4 more
core   +1 more source

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