Results 181 to 190 of about 10,948,845 (303)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Reclaiming legacy and envisioning futures in STEM education: Afrofuturism and a scholar-activist-community coalition. [PDF]

Front Sociol
Williams MR, Stewart IM, Rouse AL, Seay J, Petit LJ, Woolfolk M, Flagg DL, Jordan K, Stewart I, Morton TR.   +9 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

The Use of Speculative Fiction in Future-Focused Health Care Research. [PDF]

J Med Internet Res
Groeneveld S, Wentzel J, Laurens M, Gemert-Pijnen LV, Verdaasdonk RM, Os-Medendorp HV, Ouden MD.   +6 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

OSeMOSYS-RDM: A reproducible workflow for robust decision making with OSeMOSYS models. [PDF]

MethodsX
Victor-Gallardo L, Salazar-Vargas A, González-Sanabria L, George JS, Quirós-Tortós J.   +4 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

International aid dependence and healthcare sustainability in Afghanistan: study protocol for a systematic review. [PDF]

BMJ Open
Rahman R, Nejadghaderi SA, Razai MS.
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Verbal autopsy instruments for 'causes and circumstances' surrounding drowning deaths in low- and middle-income countries: a scoping review. [PDF]

Inj Prev
Ray-Bennett NS, Dissanayake L, Ekezie W, MacLeod L, Mecrow T, Saunders C, Sindall R, Oporia F, Rahman A, Choudhary NI, Nantume RM, Nnaji AN, Chowdhury S, Paul B, Buckett E, Biswas I, Hoque S, Sahoo M.   +17 more
europepmc   +1 more source