Results 131 to 140 of about 2,171,100 (317)

A TRIZ Based Methodology for the Analysis of the Coupling Problems in Complex Engineering Design [PDF]

, 2009
Organised by: Cranfield UniversityConceptual design is a critical and innovative stage in engineering product and system design. In the conceptual design process, it would be ideal if all functional requirements are maintained independently according ...
Tang, X.Q., Tang, X. Q., Gao, James, Fei, Genyuan, Fei, G., Gao, James X.   +5 more
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C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Developing and applying an integrated modular design methodology within a SME

, 2007
Modularity within a product can bring advantages to the design process by facilitating enhanced design reuse, reduced lead times, decreased cost and higher levels of quality.
Yan, X.T., Whitfield, R.I., Tramsheck, R., Liggat, J.J., Duffy, A.H.B., Stewart, B., Wang, W., Whitfield, I., Liggat, J.   +8 more
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Competing in Engineering Design – the Role of Virtual Product Creation [PDF]

, 2009
Organised by: Cranfield UniversityProduct creation is facing the next level of fundamental changes. Global demands are growing substantially to achieve energy efficient and sustainable value creation networks for products, production and services ...
Krause, F. L., Stöckert, H., Kind, C., Müller, P., Rothenburg, U., Stark, R.   +5 more
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Design and DSP Implementation of Fixed-Point Systems

EURASIP Journal on Advances in Signal Processing, 2002
This article is an introduction to the FRIDGE design environment which supports the design and DSP implementation of fixed-point digital signal processing systems.
Coors Martin, Keding Holger, Lüthje Olaf, Meyr Heinrich   +3 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Methodology for architecture development for product design [PDF]

, 2000
Thesis (S.M.)--Massachusetts Institute of Technology, System Design & Management Program, 2000.Includes bibliographical references (p. 101-104).An integrative methodology for architecture development in a product development environment is described. The
Martin, Michael J. (Michael John), 1962-
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