Results 161 to 170 of about 2,171,100 (317)

An Age-Adapted Co-Design Methodology for Community Health Research Involving Older Adults With Type 2 Diabetes. [PDF]

Health Expect
Niu J, Yin Y, Wang S.
europepmc   +1 more source

Social system design methodology for transitioning to a new social structure - a holistic urban living lab approach to the well-being city. [PDF]

Front Sociol, 2023
Kimura A, Haraguchi H, Yamauchi Y, Matsuura K.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Modelling iteration in engineering design

, 2007
This paper examines design iteration and its modelling in the simulation of New Product Development (NPD) processes. A framework comprising six perspectives of iteration is proposed and it is argued that the importance of each perspective depends upon ...
Eckert, C. M., Wynn, D. C., Clarkson, P. J.   +2 more
core  

Customized positioning of the glenoid component in reverse shoulder arthroplasty: a new computer aided design methodology. [PDF]

Int Orthop
Cirello A, Ingrassia T, Rovere G, Nalbone L, Camarda L, Mirulla IA, Nigrelli V, Ricotta V, Tantillo M.   +8 more
europepmc   +1 more source

Computational Prodrug Design Methodology for Liposome Formulability Enhancement of Small-Molecule APIs. [PDF]

Mol Pharm, 2023
Balouch M, Storchmannová K, Štěpánek F, Berka K.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Nature inspired design methodology for a wide field of view achromatic metalens. [PDF]

Nanophotonics
Engelberg J, Mazurski R, Levy U.
europepmc   +1 more source

Adapting co-design methodology to a virtual environment: co-designing a communication intervention for adult patients in critical care. [PDF]

Res Involv Engagem, 2023
Istanboulian L, Rose L, Yunusova Y, Dale C.   +3 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source