Results 171 to 180 of about 1,535,464 (268)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

How to Design (and Analyze) a Business Experiment

, 2015
This is the author accepted manuscript. The final version is available from Harvard Business Publishing via the DOI in this recordThe rise of experimental evaluations within organizations — or what economists refer to as field experiments — has the ...
Luca, M, Hauser, O
core  

Parametric Design and Experiment on Compression Performance of Hierarchical Origami Honeycomb Structures. [PDF]

Materials (Basel)
Lu X, Yang Y, Peng X.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Results of REXUS12's Suaineadh Experiment : Deployment of a spinning space web in micro gravity conditions

, 2012
On the 19th of March 2012, the Suaineadh experiment was launched onboard the sounding rocket REXUS12 (Rocket Experiments for University Students) from the Swedish launch base ESRANGE in Kiruna. The Suaineadh experiment served as a technology demonstrator
Tibert, Gunnar, Sinn, Thomas, Vasile, Massimiliano, McRobb, Malcolm, Wang, Junyi, Wujek, Adam, Rogberg, Fredrik, McRobb, M., Skogby, Jerker   +8 more
core  

Design and experiment of a comb-and-scrape Idesia Polycarpa Maxim threshing device. [PDF]

Sci Rep
Yang G, Wu D, Xu W, Tang Y.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Design and experiment of a novel intelligent device suitable for automation vegetable plug seedling. [PDF]

PLoS One
Haifei Q, Zhike N, Xiandong C, Bo L, Yifan Z, Feiyang L, Jiajun Z.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Optimized design and experiment of a controllable rotary tube strip fertilizer spreader for hilly mountainous terrain. [PDF]

Sci Rep
Dun G, Gao S, Ji X, Sun H, Wei Y, Sheng Q, Zhang C, Ma C, Li X, Wang L, Yu Z, Li H, Ma C.   +12 more
europepmc   +1 more source