Results 151 to 160 of about 168,505,770 (297)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A design of experiments approach to production of medicinal bioactives in <i>Mitragyna speciosa</i> (Korth.) Havil. [PDF]
Pharm BiolGiebelhaus RT +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The D-optimal design of blocked and split-plot experiments with mixture components. [PDF]
So far, the optimal design of blocked and split-plot experiments involving mixture components has received scant attention. In this paper, an easy method to construct efficient blocked mixture experiments in the presence of fixed and/or random blocks is ...
Goos, Peter, Donev, AN
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From Screening to Optimization: Strategic Implementation of Design of Experiments (DOE) for Robust Nanoparticle Formulation. [PDF]
Polymers (Basel)Gupta R, Sarkar M, Xie H.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
DOE Openness: Human Radiation Experiments
, 2009 This website is the result of a project started in 1994 by the Department of Energy's Office of Human Radiation Experiments. The purpose of the group was to research experiments done to test the effects of radiation on humans and to compile ...
United States. Department of Energy. Office of Human Radiation Experiments.
core
Benchmarking supervised classifiers within a design-of-experiments framework: Robust statistical inference in text mining. [PDF]
MethodsXSabatini AM.
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
DYNO-MILL-Assisted Mechanochemistry: Design of Experiments Optimization for Sustainable Synthesis of Pyrrolo[3,4-c]pyrazoles. [PDF]
ChemSusChemPandey R +5 more
europepmc +1 more source