Results 271 to 280 of about 4,561,954 (333)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Efficient Process Development of Abiraterone Acetate by Employing Design of Experiments. [PDF]

ACS Omega
Komati SK, Madhra MK, Manda A, Venkata Annapurna SC, Senadi GC, Maruthapillai A, Maruthapillai A, Bandichhor R.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simulation models. [PDF]

Sci Rep
Xu X, Li D, Bi J, Moeckel M.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Remote Sensing of Nitric Acid and Temperature via Design of Experiments, Chemometrics, and Raman Spectroscopy. [PDF]

ACS Omega
Russell DV, Sadergaski LR, Einkauf JD, Delmau LH, Burns JD.   +4 more
europepmc   +1 more source

A standard format for design and evaluation of pond experiments

, 1992
J.P. Szyper
openalex   +1 more source

Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chromatographic Method Development. [PDF]

Molecules
Passerine BFG, Breitkreitz MC.
europepmc   +1 more source

Cryogenic Design for the Neutron Electric Dipole Moment Experiment

, 2012
D. P. Kendellen
openalex   +1 more source

A Reconfigurable Mechanical Structure Inspired by the Mechanism of Rubik's Cube: Design, Analysis and Experiment

Miao Song, Yan Qing Wang, Yunlong Li, Quan Wang   +3 more
openalex   +1 more source