Results 191 to 200 of about 168,133,245 (277)

A design of experiments approach to production of medicinal bioactives in <i>Mitragyna speciosa</i> (Korth.) Havil. [PDF]

Pharm Biol
Giebelhaus RT, Brown PN, Ali M, Dodds AM, Erland LAE.   +4 more
europepmc   +1 more source

Biographies, ontological security and the socio‐spatial politics shaping teachers' mobility in remote Australia

British Educational Research Journal, EarlyView.
Abstract The global teacher shortage continues to intensify, with disparate impacts across geographic and socio‐economic communities. In Queensland, Australia, where this study originates, post‐COVID teacher shortages have intensified workforce pressures, leaving several regional, rural and remote schools as some of the ‘hardest‐to‐staff’ in the ...
Matthew Readette, Reece Mills, Terri Bourke, Simone White, Martin Mills, Lisa van Leent   +5 more
wiley   +1 more source

A data-driven evaluation of optimization techniques in cell culture media. [PDF]

Bioinformatics
Parsaee A, Stahn M, Amirvaresi A, Ovissipour R, Staszak D.   +4 more
europepmc   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Impact of CPPs on primary human NK cell CQAs during cell expansion - an experimental study using design of experiments. [PDF]

Front Bioeng Biotechnol
Mattert G, Schaffer C, Szarzynski A, von Werz V, Spadiut O, Pörtner R, Dammermann W.   +6 more
europepmc   +1 more source

Combinatorial Metabolic Engineering of Alkane Biosynthesis in the Osmotolerant Yeast Debaryomyces hansenii CBS 767

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Debaryomyces hansenii is a yeast with diverse potential applications like producing oleochemicals from biomass. Yet, combinatorial metabolic engineering in D. hansenii is limited because, like many nonconventional organisms, key genomic data and genetic elements are missing. Here, we report phenotypic characterization, genomic integration loci,
Zekun Li, Nilesh Kumar Sharma, Sarah Weintraub, Eric Young   +3 more
wiley   +1 more source

Milling-Induced Chitosan-HPMC Microstructural Organisation Determines the Stability Window of Concentrated Azelaic Acid Nanosuspensions. [PDF]

Pharmaceutics
Miočić S, Rašić A, Torić J, Abrami M, Ferderber K, Cetina-Čižmek B, Grassi M, Filipović-Grčić J.   +7 more
europepmc   +1 more source

Isolating T‐Cell Potent Lentiviral Vector Subpopulations through Rational Design of Nanofiber Anion‐Exchange Adsorbents

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Generation of CAR‐T cell therapies relies predominantly on lentiviral vectors (LVs). As in vivo CAR‐T trials progress, demand for larger quantities of higher‐potency LV is expected. However, primary capture by anion‐exchange chromatography (AIEX) remains a major manufacturing bottleneck from use of adsorbents not tailored to LVs, leading to ...
George Pamenter, Gyorgy Ovari, Anurag Kulkarni, Thomas Williams‐Fegredo, Carol Knevelman, Kyriacos Mitrophanous, Lee Davies, Farzad Foroutan, Matthew Townsend, Stephen Goldrick, Daniel G. Bracewell   +10 more
wiley   +1 more source

Bayesian Optimization of a Suzuki Coupling for the Industrial Synthesis of a Sartan Drug Intermediate. [PDF]

ACS Omega
Molins M, Fernandez-Garcia J, Vázquez D, Berzosa X.   +3 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source