Results 91 to 100 of about 13,502,506 (299)

Patterns and Themes in Designing with Children [PDF]

Foundations and Trends® in Human–Computer Interaction, 2020
A host of design approaches have been developed to support involving children in the design of new technologies. Unique approaches tend to be developed to involve new “audiences” of children – of different ages, with different abilities, at different levels of involvement – in the design process.
openaire   +3 more sources

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Performance of API Design for Interoperability of Medical Information Systems

Applied Sciences
After the experience of the COVID-19 pandemic, it has become evident that efficient and secure interoperability of medical information is crucial for effective diagnoses and medical treatments.
Leticia Dávila Nicanor, Abraham Banda Madrid, Jesús E. Martínez Hernández, Irene Aguilar Juárez   +3 more
doaj   +1 more source

Precise Modeling of Design Patterns [PDF]

, 2000
Design Patterns are now widely accepted as a useful concept for guiding and documenting the design of object-oriented software systems. Still the UML is ill-equipped for precisely representing design patterns. It is true that some graphical annotations related to parameterized collaborations can be drawn on a UML model, but even the most classical GoF ...
Le Guennec, Alain, Sunyé, Gerson, Jézéquel, Jean-Marc   +2 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Universal Design Patterns: Designing a Web-Based Tool with Architects

, 2011
The implementation of Universal Design in design practice requires a number of tools that provide support to designers throughout the design process. In recent years, several studies have been carried out, determining methods to help designers select ...
E. Verdonck, F. Hubert
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Compositional aspect-oriented design pattern properties

Lietuvos Matematikos Rinkinys, 2009
In this publication we analyze traditional object-oriented design pattern aspectual compositions implemented in object-oriented framework. The main task is to look whether the design pattern compositions present concern duplications, and if they do then ...
Žilvinas Vaira , Albertas Čaplinskas
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source