Results 51 to 60 of about 14,350,671 (304)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Challenge course : research, design, and plan [PDF]

open access: yes, 2013
Ball State University offers an extensive variety of recreational and leadership opportunities but no challenge course. Administrators have determined that there is a need and interest in the challenge course facility and its curriculum.
Edenfield, Jessica M.
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Design-Based Research

open access: yes, 2015
Educational design research is a genre of research in which the iterative development of solutions to practical and complex educational problems provides the setting for scientific inquiry. The solutions can be educational products, processes, programs or policies.
Reeves, Thomas, McKenney, Susan
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Design Research: The Next 500 Years

open access: yesARENA Journal of Architectural Research, 2022
In contemporary discourse and practice it is familiar to discuss design research as if it is new to architecture. But this is to ignore the history of the architect.
Jonathan Hill
doaj   +1 more source

Enhancing the design curriculum through pedagogic research [PDF]

open access: yes, 2002
Pedagogic research is becoming increasingly recognised as an important aspect of academic life. Many generic studies (Marton, Saljo, Entwistle, Biggs, Gibbs, Prosser, Trigwell et al), focusing on broad concepts of student learning, have found a purchase ...
Davies, Allan
core  

Design diversity: an update from research on reliability modelling [PDF]

open access: yes, 2001
Diversity between redundant subsystems is, in various forms, a common design approach for improving system dependability. Its value in the case of software-based systems is still controversial. This paper gives an overview of reliability modelling work
B Littlewood   +9 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman   +8 more
wiley   +1 more source

Under the umbrella: components of empathy in psychology and design

open access: yesDesign Science, 2022
Empathy is argued to be a key factor for a successful design discussion. However, such causality cannot be empirically proven based on how empathy is currently defined in design community.
Álvaro M. Chang-Arana   +3 more
doaj   +1 more source

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