Results 101 to 110 of about 166,983 (266)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
DynDSE: Automated Multi-Objective Design Space Exploration for Context-Adaptive Wearable IoT Edge Devices. [PDF]
Sensors (Basel), 2020 Schiboni G, Suarez JC, Zhang R, Amft O.
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Design Space Exploration of the Dragonfly Topology
, 2017 We investigate possible options of creating a Dragonfly topology capable of accommodating a specified number of end-points. We first observe that any Dragonfly topology can be described with two main parameters, imbalance and density, dictating the distribution of routers in groups, and the inter-group connectivity, respectively.
Min Yee Teh +3 more
openaire +2 more sources
Use of Bayesian Networks to Understand Sustainability Requirements
Engineering ProceedingsSustainability is a key requirement in contemporary engineering design, but it is difficult to quantify due to its multidimensionality. We propose the application of Bayesian Networks for modeling the cause and effect of engineering systems and their ...
Andrea Spinelli, Timoleon Kipouros
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Exploring the Design Space of Transition Matching
CoRRTransition Matching (TM) is an emerging paradigm for generative modeling that generalizes diffusion and flow-matching models as well as continuous-state autoregressive models. TM, similar to previous paradigms, gradually transforms noise samples to data samples, however it uses a second ``internal'' generative model to implement the transition steps ...
Uriel Singer, Yaron Lipman
openaire +2 more sources
Registry in a tube: multiplexed pools of retrievable parts for genetic design space exploration. [PDF]
Nucleic Acids Res, 2017 Woodruff LBA +7 more
europepmc +2 more sources
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source