Results 81 to 90 of about 11,312,526 (253)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of design parameters on the global performances of low-speed counter-rotating axial-flow fans [PDF]

open access: yes, 2014
The present work aims at experimentally investigating the effects of some parameters on the performances of a counter-rotating stage, and on the instationary flow between the rotors.
BAKIR, Farid   +5 more
core   +1 more source

A Diagnosing Method for Phased Antenna Array Element Excitation Amplitude and Phase Failures Using Random Binary Matrices

open access: yesIEEE Access, 2020
A diagnosing method for phased antenna array element failures is proposed. The element excitation amplitudes and phases are reconstructed by a compressed sensing based approach, in which the radiated electric fields of the array are sampled by a single ...
Can Xiong, Gaobiao Xiao
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Participatory Road Design: An Investigation into Improving Roads, Drivers' Attitude and Behaviour Using Partiticipatory Design [PDF]

open access: yes, 2009
Improving road safety is currently based mostly on Education, Enforcement and Engineering or the 3 Es. Despite these measures having saved millions of lives since their inception in around 1915, millions of people are still injured or killed in accidents
de Jong, Dennis
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Analyzing Electromagnetic Systems on Electrically Large Platform Using a GTM-PO Hybrid Method with Synthetic Basis Functions

open access: yesInternational Journal of Antennas and Propagation, 2014
A hybrid method of generalized transition matrix (GTM) and physical optics (PO) with synthetic basis functions (SBF) is proposed to analyze electromagnetic systems on electrically large platforms.
Shang Xiang, Gaobiao Xiao, Junfa Mao
doaj   +1 more source

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