Results 71 to 80 of about 2,126,236 (343)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

On the Pareto-Optimal Beam Structure and Design for Multi-User MIMO Interference Channels

, 2012
In this paper, the Pareto-optimal beam structure for multi-user multiple-input multiple-output (MIMO) interference channels is investigated and a necessary condition for any Pareto-optimal transmit signal covariance matrix is presented for the K-pair ...
Park, Juho, Sung, Youngchul
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Evaluating the Impact of Design Changes in Remote Sensing Satellites Using Design Structure Matrix [PDF]

فصلنامه علوم و فناوری فضایی
Designing complex systems, especially in the space industry, is accompanied by challenges such as changes in components and their interactions. This article aims to facilitate the design of complex systems by introducing and examining the design ...
Mohammad Sayanjali
doaj   +1 more source

Optimal Tx-BF for MIMO SC-FDE Systems

, 2013
Transmit beamforming (Tx-BF) for multiple-input multiple-output (MIMO) channels is an effective means to improve system performance. In frequency-selective channels, Tx-BF can be implemented in combination with single-carrier frequency-domain ...
Bhargava, Vijay K., Schober, Robert, Wu, Peiran   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Healthcare process modularization using design structure matrix

Advanced Engineering Informatics, 2019
Abstract The healthcare industry is confronted with the challenge of offering customized services while in the meantime to control increasing healthcare costs. Modularization is an important approach to reduce healthcare costs and improve patient-centered services via decreasing process complexity and enhancing flexibility through configuring pre ...
Zhang, Xiaojin, Ma, Shuang, Chen, Songlin   +2 more
openaire   +2 more sources

Design Structure Matrix (DSM) Approach to Design a Surgery Robot

, 2023
Abstract The product development process (PD) can be viewed as an optimization problem to minimize design loops. Nowadays, the complexity of the system components has increased due to technological progress. These complex interconnections between the different components of the system can complicate and prolong the design process. In such cases,
Forough Zamani, Borhan Beigzadeh
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source