Results 131 to 140 of about 11,254,833 (302)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Study on the Sound Therapy Interaction Design to Alleviate Homesickness: The HomeSeek App among Chinese Users

open access: yesApplied Sciences
Research in the field of psychological health care has confirmed that chronic homesickness can exacerbate emotional problems. However, there is a lack of diverse products in the design field that can effectively address the issue of alleviating ...
Ye Zhou, Ken Nah, Suqin Tan
doaj   +1 more source

Aeroassisted-vehicle design studies for a manned Mars mission [PDF]

open access: yes
An aerobrake design that has matured over several years of development accounting for all of the important flow phenomenology which are characteristic of aerobraking vehicles is proposed as the mission baseline.
Menees, Gene P.
core   +1 more source

Visual Research: An Introduction to Research Methodologies in Graphic Design [PDF]

open access: yes, 2005
"Visual Research: An Introduction to Research Methodologies in Graphic Design" is a guide to the practice of researching for graphic design projects. This book explains the key terms and theories that underlie design research; examining the importance of
Bestley, Russ, Noble, Ian
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Systematic review and meta-analysis of the impact of STEM education on students learning outcomes

open access: yesFrontiers in Psychology
IntroductionSTEM education’s impact on student learning outcomes is nuanced, with differentiated effects across outcome types and academic levels.MethodsThis study uses meta-analysis to systematically analyse 66 experimental and quasi-experimental ...
Xin Cao, Honglei Lu, Qian Wu, Yen Hsu
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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