Results 171 to 180 of about 25,387,525 (309)

Designing for impact: Introducing translational design studies. [PDF]

J Clin Transl Sci
Volkov B, Adatorwovor R, Michener L, Lindsell C, Moore JB.   +4 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Preliminary of User Interface Design for Picture Archiving and Communication System

, 2013
[[abstract]]In order to gain entry to modern and technology, medical imaging technology not only has to economically storing, and conveniently accessing, images from multiple modalities, but also focus on user’s experience and interaction.
Lin, Wei-Chun Winine;Lee, Yuan-Zone
core  

Improving Assessment of Vaccine Effectiveness by Coupling Test-negative Design Studies with Survival Models. [PDF]

Epidemiology
Song S, Hitchings MDT, Yang Y, Longini IM, N3C consortium.   +4 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Identification of the causal odds ratio in test-negative-design studies of COVID-19 vaccine effectiveness. [PDF]

Int J Epidemiol
Delaunay CL, Nunes B, Monge S, de Lange M, Túri G, Machado A, Latorre-Margalef N, Mlinarić I, Lazar M, Botella Rocamora P, Erdwiens A, Sève N, Domegan L, Martínez-Baz I, Hooiveld M, Oroszi B, Guiomar R, Sperk M, Kurečić Filipović S, Pascu C, Linares Dopido JA, Dürrwald R, Rameix-Welti MA, McKenna A, Castilla J, van Hagen C, Knol M, Kaczmarek M, Kissling E.   +28 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Initial evidence of effects of a novel digital behavioural treatment for chronic pain: A series of replicated randomized single-case experimental design studies. [PDF]

Digit Health
Al Sharaa H, Bartels SL, Onghena P, Taygar A, Engman L, Flink I, Petersson S, Boersma K, McCracken LM, Simons L, Vlaeyen JWS, Wicksell RK.   +11 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Influence of Renal or Hepatic Impairment on the Pharmacokinetics of Iclepertin (BI 425809): Results from Two Phase I Open-Label, Non-randomised, Single Dose, Parallel Design Studies. [PDF]

Drugs R D
Choi H, Madari S, Daalman E, English BA, Halabi A, Hohl K, Shatillo Y, Weidinger N, Desch M.   +8 more
europepmc   +1 more source