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Designing Physiogenomic Studies

Pharmacogenomics, 2006
‘The increase in sample size needed to account for multiple testing is relatively modest, increasing only logarithmically with the number of markers, thus remaining quite feasible even for genome-wide SNP arrays.’ Micro- and nano-array technologies can produce millions of biomarkers for biomedical research.
Theodore R, Holford   +2 more
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Study Design for Sequencing Studies

2016
Once a biochemical method has been devised to sample RNA or DNA of interest, sequencing can be used to identify the sampled molecules with high fidelity and low bias. High-throughput sequencing has therefore become the primary data acquisition method for many genomics studies and is being used more and more to address molecular biology questions.
Loren A, Honaas   +2 more
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Study Design Algorithm

Journal of Lower Genital Tract Disease, 2015
To aid authors in correctly naming their study design, to assist readers and reviewers who must decide what the design was for some published studies, and to provide consistency in evaluating the design of published studies, especially for those conducting systematic reviews and evidence synthesis.An annotated algorithm method is used to prompt serial ...
Jeff, Andrews, Frances E, Likis
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Design of toxicokinetic studies

Xenobiotica, 1990
1. Toxicokinetics is defined as pharmacokinetic studies in animals during actual toxicity studies or under conditions mimicking them (species, duration, dose level, etc.). 2. Toxicology studies require toxicokinetics to check whether systemic exposure reflects administered dose.
D A, Smith, M J, Humphrey, C, Charuel
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Designing a research study

The Indian Journal of Pediatrics, 2000
There are 10 steps to consider in any research study. These steps can be used to perform a critical appraisal of a published paper, or to design your study in the first place. The use of a simple system such as this can ensure that biases in study design are avoided and that an appropriate study is developed. (1) What is the study hypothesis?
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