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Designing Physiogenomic Studies

Pharmacogenomics, 2006
‘The increase in sample size needed to account for multiple testing is relatively modest, increasing only logarithmically with the number of markers, thus remaining quite feasible even for genome-wide SNP arrays.’ Micro- and nano-array technologies can produce millions of biomarkers for biomedical research.
Theodore R, Holford   +2 more
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Study Design for Sequencing Studies

2016
Once a biochemical method has been devised to sample RNA or DNA of interest, sequencing can be used to identify the sampled molecules with high fidelity and low bias. High-throughput sequencing has therefore become the primary data acquisition method for many genomics studies and is being used more and more to address molecular biology questions.
Loren A, Honaas   +2 more
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Study Design Algorithm

Journal of Lower Genital Tract Disease, 2015
To aid authors in correctly naming their study design, to assist readers and reviewers who must decide what the design was for some published studies, and to provide consistency in evaluating the design of published studies, especially for those conducting systematic reviews and evidence synthesis.An annotated algorithm method is used to prompt serial ...
Jeff, Andrews, Frances E, Likis
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Designing a research study

The Indian Journal of Pediatrics, 2000
There are 10 steps to consider in any research study. These steps can be used to perform a critical appraisal of a published paper, or to design your study in the first place. The use of a simple system such as this can ensure that biases in study design are avoided and that an appropriate study is developed. (1) What is the study hypothesis?
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Designing a Research Study

The Diabetes Educator, 2008
Diabetes educators and advanced-practice nurses in diabetes care often participate in clinical research. The purpose of this article is to provide a broad overview of important decisions in planning a research study. The research process is reviewed, including the conceptual phase, the design and planning phase, the empirical phase, the analytic phase,
Robin, Whittemore, Gail D'Eramo, Melkus
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Design of toxicokinetic studies

Xenobiotica, 1990
1. Toxicokinetics is defined as pharmacokinetic studies in animals during actual toxicity studies or under conditions mimicking them (species, duration, dose level, etc.). 2. Toxicology studies require toxicokinetics to check whether systemic exposure reflects administered dose.
D A, Smith, M J, Humphrey, C, Charuel
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Considerations of Study Design

Nutrition in Clinical Practice, 2007
Research projects attempt to answer specific questions. The particular study design that is selected will depend in large measure on the nature of the question and the time and resources available. There are 5 common categories of clinical questions; they relate to etiology, prognosis, utility of diagnostic tests, efficacy of proposed interventions ...
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The Design of Inheritance Studies

Biometrical Journal, 1983
In a study of the inheritance of a quantitative trait in the general population, data are collected from the three‐generational nuclear families of many index cases. The question arises as to the optimal choice of family members to maximise the power of testing a hypothesis of polygenic and environmental effects against an alternative of environmental ...
Simpson, J. M., McGilchrist, C. A.
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