Results 31 to 40 of about 3,686 (261)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Teaching Architectural Design Studio Remotely: The Introduction to Architectural Design Course at METU

Journal of Design Studio, 2020
This paper aims to briefly assess the potentials and limits of online learning environment for studio education by focusing on the case of 2019-20 spring semester studio of Introduction to Architectural Design course at Middle East Technical University’s Department of Architecture.
Esin Komez Daglioglu, Ekin Pinar, Ipek Gursel Dino, Pelin Yoncaci Arslan, Funda Bas Butuner   +4 more
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Design and Implementation of a Studio-Based General Chemistry Course

Journal of Chemical Education, 2007
Most students taking general chemistry courses do not intend to pursue careers in chemistry; in fact, they are more likely to end up in positions where they fund, write, or vote for chemical research and policies. Our profession continues to ask how we can teach students scientific reasoning skills and chemical understanding in general chemistry that ...
Gottfried, Amy C., Sweeder, Ryan D., Bartolin, Jeffrey M., Hessler, Jessica A., Reynolds, Benjamin P., Stewart, Ian C., Coppola, Brian P., Banaszak Holl, Mark M.   +7 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pandemic experimentalism: decentering studio art education in an ongoing global emergency

Artnodes, 2023
After eighteen months of online art education during the COVID-19 pandemic, the authors consider Form and Time, a required first-year studio art course at OCAD University in Toronto, as a case study within global practices of reconfiguration and ...
Judith Doyle, Simone Jones, Elizabeth Lopez   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Design Studio Course Model Designed for the First Semester of Interior Architecture Departments

Turkish Studies-Educational Sciences, 2022
Yıllardır, eğitimciler ve araştırmacılar eğitim alanında yeni modeller geliştirerek eğitim alanındaki sorunları çözümlemeye çalışmaktadır. Tasarım eğitiminde de bu durum aynı olmakla birlikte, hala çözüm aranan birçok problem bulunmaktadır. İçmimarlık disiplini özelinde, öğrencilerin test çözerek üniversiteye girmesi ve tüm ...
openaire   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The effect of environmental control course on architectural design projects (Case study environmental control course - Canadian International Collage – Egypt)

Results in Engineering
It is a global strategy to save the environment through sustainable designs; this approach must begin throughout the college phase and progress through their professional career.
Enas El-Halwagy
doaj   +1 more source