Results 141 to 150 of about 5,290,684 (266)

Creation of EmpowerMe Website to Promote Self-Efficacy in Survivors of Stroke: Co-Design Study. [PDF]

J Med Internet Res
Lynch EA, O'Malley A, Adey-Wakeling Z, Bonevski B, Cadilhac DA, Chamberlain S, Churilov L, Clark R, Cullen R, Godecke E, Harvey G, Jones F, Lannin NA, Larcombe S, Law J, McGrath A, Murphy L, Nesbitt K, Zacharia K, Bidargaddi N, English C.   +20 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Exploring the effects of task complexity and translation anxiety on EFL learners' translation performance: Evidence from a mixed-design study. [PDF]

PLoS One
Zhou X, Liu X.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effectiveness of Influenza Vaccines in Italy in the 2024/2025 Season: A Nationwide, Test-Negative Design Study Based on Surveillance Records. [PDF]

Influenza Other Respir Viruses
Cifo D, Mateo-Urdiales A, Puzelli S, Facchini M, Piacentini S, Giombini E, Bellini B, Fabiani M, Pezzotti P, Stefanelli P, Palamara AT, Bella A, RespiVirNet network.   +12 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development of a Cystic Fibrosis Weight Management Programme:  protocol for a co-design study. [PDF]

NIHR Open Res
Barrett J, Topping AE, Ntoumanis N, Turner AM, White H, Fenton SAM.   +5 more
europepmc   +1 more source

A study design to identify associations [PDF]

BJOG: An International Journal of Obstetrics & Gynaecology, 2018
Alexander, Melamed, Julian N, Robinson
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cultural Adaptation of a Digital Mobile App for Bipolar Disorder (PolarUs): Protocol for a Qualitative Co-Design Study. [PDF]

JMIR Res Protoc
Chau LW, Murphy JK, Morton E, Provencher MD, Raucher-Chene D, Barnes SJ, Michalak EE.   +6 more
europepmc   +1 more source