Results 171 to 180 of about 10,358,166 (300)

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

open access: yesFEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer   +7 more
wiley   +1 more source

Stakeholder perspectives on depression management: A design thinking exploration for person-centered digital health. [PDF]

open access: yesPLoS One
Moretó S   +9 more
europepmc   +1 more source

Shaping sustainable pathways. Fostering sustainable business innovation through systemic design thinking.

open access: yes
LAUREA MAGISTRALEIn risposta alle crescenti sfide ambientali e sociali del nostro tempo, questa tesi esplora come il systemic design thinking possa supportare le aziende nell’attuare un’innovazione aziendale sostenibile.
Anfossi, Dorotea
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

Using Rapid Design Thinking to Develop Virtual Reality Simulations for Managing Psychiatric Emergencies. [PDF]

open access: yesJ Med Educ Curric Dev
Hargreaves F   +6 more
europepmc   +1 more source

Think Software Think Testing Think Design

open access: yesInternational Journal of Computer Sciences and Engineering, 2019
Sushmitha S Prabhu, Zoya Kapoor
openaire   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

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