Results 141 to 150 of about 11,754 (266)

DEAD‐Box Helicase 6 Blockade in Brain‐Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity

MedComm, Volume 6, Issue 5, May 2025.
We identified four proteins (DSP, JUP, HRNR, and DDX6) that bind to amyloid‐beta (Aβ) oligomers derived from the brains of Alzheimer's disease (AD) patients. Among these four proteins, only the blockade of DEAD‐box helicase 6 (DDX6) in AD brain‐derived Aβ oligomers attenuated their neurotoxicity.
Xiaoxu Wang, Lu Dai, Na Wu, Donghui Wu, Xinyuan Wang, Xia Meng, Qilei Zhang, Jing Lu, Xiaoxin Yan, Jing Zhang, Baian Chen   +10 more
wiley   +1 more source

Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration

Molecular Cancer Research, 2020
Elevated uptake of saturated fatty acid palmitate is associated with metastatic progression of cancer cells; however, the precise signaling mechanism behind the phenomenon is unclear.
A. Nath, Amrita Oak, Kevin Y. Chen, Irene Li, R. C. Splichal, Jason Portis, S. Foster, S. P. Walton, C. Chan   +8 more
semanticscholar   +1 more source

Clinical exome performance for reporting secondary genetic findings. [PDF]

, 2014
BACKGROUND : Reporting clinically actionable incidental genetic findings in the course of clinical exome testing is recommended by the American College of Medical Genet- ics and Genomics (ACMG).
Clark, P, Fortina, Paolo, Kricka, Lj, Londin, E, Park, J. Y., Park, Jy, Sponziello, Marialuisa   +6 more
core   +1 more source

The Diminution of R‐Loops Generated by LncRNA DSP‐AS1 Inhibits DSP Gene Transcription to Impede the Re‐Epithelialization During Diabetic Wound Healing

Advanced Science
Re‐epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms in the context of diabetic wounds remain elusive.
Chen Yang, Hong Lian, Hengli Luo, Chenlin Song, Jianghong Lin, Zhuoxian Liang, Yulin Yang, Xiaosi Hong, Shaohua Li, Yanbo Chen, Liangyan Wu, Li Yan, Sifan Chen, Meng Ren   +13 more
doaj   +1 more source

Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner [PDF]

, 2011
By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds.
Destici Eugin, Oklejewicz Małgorzata, Saito Shoko, van der Horst Gijsbertus T.J., 齋藤 祥子   +4 more
core   +1 more source

LncRNA MIR4435-2HG targets desmoplakin and promotes growth and metastasis of gastric cancer by activating Wnt/β-catenin signaling

Aging, 2019
Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of gastric cancer; however, their mechanisms of action remain largely unknown. The aim of this study was to identify lncRNAs involved in the tumorigenesis of gastric cancer and to ...
Haiyong Wang, Mengjie Wu, Yimin Lu, Kuifeng He, Xiaolu Cai, Xiongfei Yu, Jun Lu, L. Teng   +7 more
semanticscholar   +1 more source

Are There Clinical Cardiac Complications From Too Much Exercise? [PDF]

, 2017
The dose-response association between physical activity and cardiovascular outcomes is well described (10). As little as 15 min·d−1 of moderate-intensity exercise significantly lowers the risk for cardiovascular morbidity and mortality.
Eijsvogels, TM, Thompson, PD
core   +1 more source

Arrhythmogenic Ventricular Cardiomyopathy

JACC: Case Reports, 2021
After a 20-year-old woman suddenly died, autopsy showed characteristic findings of biventricular arrhythmogenic cardiomyopathy. Screening of her family members revealed the same desmoplakin gene mutation and imaging abnormalities predominantly involving ...
Aranyak S. Rawal, MD, Tara VanCleave, BS, Neeraja Yedlapati, MD, Jeffery E. Saffitz, MD, PhD, William James Craigen, MD, PhD, John L. Jefferies, MD, MPH   +5 more
doaj  

De novo heterozygous desmoplakin mutations leading to Naxos-Carvajal disease

Swiss Medical Weekly, 2012
STUDY/PRINCIPLES: Arrythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an autosomal-dominantly inherited disease caused by mutations in genes encoding desmosomal proteins and is characterised by fibrofatty replacement occurring ...
Dagmar I Keller, Dimitri Stepowski, Christian Balmer, Francoise Simon, Joelle Guenthard, Fabrice Bauer, Peter Itin, Nadine David, Valérie Drouin-Garraud, Véronique Fressart   +9 more
doaj   +1 more source

Proteome-based plasma biomarkers for Alzheimer's disease [PDF]

, 2006
Alzheimer's disease is a common and devastating disease for which there is no readily available biomarker to aid diagnosis or to monitor disease progression.
A. Hye, Aliferis, Armstrong, Baird, Bauer, Bertram, Biroccio, Blennow, C. E. Shaw, C. Foy, C. Hooper, Cucullo, D'Andrea, DeKosky, Edwards, Esparza-Gordillo, F. Rijsdijk, Finehout, G. Hamilton, H. L. Byers, Hageman, Haines, Hampel, Hampel, Hampel, Irizarry, J. Campbell, J. Powell, Johnson, Klaver, Liu, Loeffler, Lopez, M. Causevic, M. Poppe, M. Thambisetty, M. Ward, Mattila, Mehta, Mullins, N. Archer, Nath, Newsome, P. Sham, R. G. Brown, Reisberg, Rodriguez de Cordoba, S. Banner, S. J. Tabrizi, S. Lovestone, S. Lynham, Scacchi, Strauss, Strohmeyer, Strohmeyer, Sunderland, Szafranski, Tam, Yang, Yocum, Zhang, Zipser, Zolotarjova   +62 more
core   +1 more source