Results 251 to 260 of about 11,754 (266)

Desmoplakin Cardiomyopathy in Pediatric Patients: A Distinct, Underrecognized Cohort of Arrhythmogenic Cardiomyopathy

Circulation: Arrhythmia and Electrophysiology
BACKGROUND: DSP cardiomyopathy is a distinct subset of arrhythmogenic cardiomyopathy, reported primarily in adults, that has predominantly left ventricular involvement and features of myocarditis.
N. Choi, Sara Cherny, C. I. Berul, William R. Goodyer, Taylor S. Howard, Anna Joong, L. Liberman, Eric S. Silver, C. Villa, Teresa M Lee, Warren Zuckerman   +10 more
semanticscholar   +1 more source

Desmoplakin cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy: two distinct forms of cardiomyopathy?

Minerva cardiology and angiology, 2021
The confirmation of a hypothesis that desmoplakin-related (DSP) cardiomyopathy could represent a distinct clinical entity from the classical, RV-dominant, form of arrhythmogenic cardiomyopathy (ACM), most frequently caused by PKP2 mutations, would ...
D. Kukavica, A. Trancuccio, Carlo Arnò, A. Latini, A. Mazzanti, S. Priori   +5 more
semanticscholar   +1 more source

Structure of Desmoplakin and Its Association with Intermediate Filaments

The Journal of Dermatology, 1992
AbstractDesmoplakins (DPs) I and II are two major related proteins located in the desmosomal plaque where they have been proposed to play a role in attaching intermediate filaments (IF) to the inner cell surface. The predicted amino acid sequence of DP was obtained by analysis of overlapping cDNA clones.
Thaddeus S. Stappenbeck, Kathleen J. Green, D. A.D. Parry, Maria Luisa A. Virata   +3 more
openaire   +3 more sources

Desmoplakins of Epithelial and Myocardial Desmosomes are Immunologically and Biochemically Related

Differentiation, 1982
Guinea pig antibodies against desmoplakins from bovine muzzle epidermis showed specific reaction in several epithelial tissues with desmoplakin I (Mr 250,000) and desmoplakin II (Mr 215,000). By immunofluorescence microscopy, prominent punctate staining was observed in various lines of cultured epithelial cells, revealing desmosomal junctions at sites ...
Werner W. Franke, Helga Mueller, Erika Schmid, R. Moll, Juergen Kartenbeck, Dorothea L. Schiller   +5 more
openaire   +3 more sources

Desmoplakin II expression is not restricted to stratified epithelia

Journal of Cell Science, 1990
ABSTRACT Desmosomes are major intercellular junctions found in association with intermediate filaments in epithelial, cardiac and arachnoidal tissue. Desmoplakins I and II (DPI and II) are highly related proteins localized in the innermost part of the desmosomal plaque and are candidates for linking intermediate filaments (IF) to the ...
Laura A. Nilles, Brigitt D. Angst, Kathleen J. Green   +2 more
openaire   +3 more sources

VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions

Journal of Cell Science, 1998
ABSTRACT Vascular endothelial cells assemble adhesive intercellular junctions comprising a unique cadherin, VE-cadherin, which is coupled to the actin cytoskeleton through cytoplasmic interactions with plakoglobin, β-catenin and α-catenin.
Elayne A. Bornslaeger, Andrew P. Kowalczyk, Jeffrey E. Borgwardt, Pilar Navarro, Daniel S. Kopp, Elisabetta Dejana, Kathleen J. Green   +6 more
openaire   +3 more sources

Fulminant Myocarditis Unmasking Adult-Onset Still's Disease and Desmoplakin Truncation.

Circulation Cardiovascular Imaging, 2023
D. Catapano, Marco Tontodonato, S. D’Elia, E. Pezzullo, Francesco Ciaramella, S. Vettori, R. Bussani, G. Ciucci, C. Collesi, G. Sinagra, P. Golino, F. Loffredo   +11 more
semanticscholar   +1 more source

Deconstructing desmoplakin

Nature Cell Biology, 2001
S, Hatsell, P, Cowin
openaire   +2 more sources

Pemphigus vulgaris with autoantibodies to desmoplakin. [PDF]

British Journal of Dermatology, 2001
Jong Hoon Kim, Masayuki Amagai, Y. L. Chung, Soo Chan Kim, N. J. Cho   +4 more
openaire   +1 more source

Desmoplakin mutations in cardiac fibroblasts cause TGFβ1-mediated pathological fibrogenesis in desmoplakin cardiomyopathy via beclin-1 regulation

AbstractBackgroundPathological fibrosis is a major finding in cardiovascular diseases and can result in arrhythmia and heart failure. Desmosome gene mutations can lead to arrhythmogenic cardiomyopathy (ACM). Among ACM, pathogenic desmoplakin (DSP) variants cause a distinctive cardiomyopathy with excessive cardiac fibrosis that could precede ventricular
Chuanyu Wei, Shing-Fai Chan, Ardan M. Saguner, Corinna Brunckhorst, Firat Duru, Joseph E. Marine, Cynthia A. James, Hugh Calkins, Daniel P. Judge, Weinian Shou, Huei-Sheng Vincent Chen   +10 more
openaire   +2 more sources