Results 51 to 60 of about 1,152 (175)
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis [PDF]
The Journal of Cell Biology, 2007 Despite their importance in cell shape and polarity generation, the organization of microtubules in differentiated cells and tissues remains relatively unexplored in mammals. We generated transgenic mice in which the epidermis expresses a fluorescently labeled microtubule-binding protein and show that in epidermis and in cultured keratinocytes ...
Lechler, Terry, Fuchs, Elaine
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Respirology, Volume 31, Issue 6, Page 561-577, June 2026.ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Cardiomyopathies encompass a spectrum of myocardial disorders often attributed to underlying genetic mutations. However, genotype–phenotype discordance where the genetic profile does not align with the expected clinical presentation poses significant diagnostic, prognostic, and therapeutic challenges.
Abubakar Nazir +9 more
wiley +1 more source
Paraneoplastic Pemphigus: An Indication for Treatment in Chronic Lymphocytic Leukemia [PDF]
, 2020 Paraneoplastic disorders are rare multiorgan diseases associated with hematological malignancies such as chronic lymphocytic leukemia (CLL). Some of these paraneoplasms manifest as cutaneous lesions, appearing as a simple rash, ulcers or skin thickening.
Joseph, Gardith +4 more
core +1 more source
Desmoplakin cardiomyopathy: case report
European Heart Journal - Case ReportsAbstract Background Desmoplakin (DSP) cardiomyopathy is a distinct form of cardiomyopathy characterized by frequent left ventricular involvement with extensive fibrosis, high arrhythmic risk, and episodes of acute myocardial injury. Case summary
Ayman Helal +3 more
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International Journal of Dermatology, Volume 65, Issue 4, Page 797-805, April 2026.ABSTRACT Introduction Hailey‐Hailey disease (HHD) is a rare genodermatosis caused by mutations in the ATP2C1 gene that codes for SPCA1, a calcium transporter in the epidermis. HHD impairs quality of life, and no curative treatment exists. Methods To confirm the efficacy and safety of CO2 laser in HHD, we conducted a randomized, prospective, controlled ...
Javier Antoñanzas +7 more
wiley +1 more source
Reduced Dietary Protein Induces Changes in the Dental Proteome
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
Desmoplakin’s tail gets the message [PDF]
Journal of Cell Biology, 2015 ![Figure][1] Desmoplakin (green) normally resides at cell–cell junctions (top), but in cells that can’t methylate its tail (bottom), it gathers along intermediate filaments (red). Cells control the junction protein desmoplakin by methylating and phosphorylating its tail, [Albrecht ...
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Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases
MedComm, Volume 7, Issue 3, March 2026.This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao +19 more
wiley +1 more source
Desmoplakin I and desmoplakin II. Purification and characterization.
The Journal of biological chemistry, 1989 Desmoplakins I and II (DP1 and DP2), major cytoskeletal structural proteins concentrated in desmosomes, have been purified in milligram quantities from keratomed pig tongue epithelium. DP1 and DP2 extracted from purified desmosomes in 4 M urea were chromatographed on DEAE-cellulose and remained soluble after removal of urea during subsequent ...
E J, O'Keefe, H P, Erickson, V, Bennett
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