Results 101 to 110 of about 1,188,443 (302)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The Estimation of Prospects of Development of the Tourist Destination of Saint-Petersburg
Управленческое консультирование, 2018 The paper estimates the prospects of the development of modern tourist destination in St. Petersburg. Methodology assessment served as a well-known tool in strategic management the SWOT-analysis.
Aleksei Igorevich Balashov
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Destination brand authenticity to destination brand engagement in tourism destination
Technium Social Sciences JournalThis study examines Destination Brand Engagement (DBE) in the context of tourism primarily focusing on its outcomes rather than its antecedents. This study differs from previous studies in examines the impact of destination-centric drivers and tourist-centric perspectives.
Intan Widuri Sakti +2 more
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Téoros, 2013 De nombreuses collectivités territoriales font le choix, depuis quelques années, de développer une politique événementielle. L’objectif de cet article est de s’interroger sur la pertinence d’une telle stratégie de développement économique, c’est-à-dire ...
Nathalie Alexandre-Bourhis +2 more
doaj
Improving the Dependability of Destination Recommendations using Information on Social Aspects [PDF]
Prior knowledge of the social aspects of prospective destinations can be very influential in making travel destination decisions, especially in instances where social concerns do exist about specific destinations.
Adigun, Mathew O. +3 more
core +1 more source
Source-Channel Coding Theorems for the Multiple-Access Relay Channel
, 2013 We study reliable transmission of arbitrarily correlated sources over multiple-access relay channels (MARCs) and multiple-access broadcast relay channels (MABRCs). In MARCs only the destination is interested in reconstructing the sources, while in MABRCs
Dabora, Ron +2 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source