Results 41 to 50 of about 396,083 (241)

The impact of climate change on visitor destination selection: A case study of the Central Drakensberg Region in KwaZulu-Natal

Jàmbá, 2021
Many variables influence visitors’ destination choices, for example, affordability, attractions, health and safety, and expectancies. Amongst the indirect influences in destination choice by tourists, climate change is perhaps the greatest factor because
Nduduzo A. Ngxongo
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Re-modelling Muslim-friendly tourism value chain ecosystem: the case study of West Sumatera, Indonesia

Cogent Social Sciences
The development of Muslim-friendly tourism destinations is an effort to differentiate products and the tourism market amidst the aggressive growth of global tourism.
Anang Sutono, Sumaryadi, Wisnu Rahtomo, Faisal Fahdian Puksi, Odang Permana   +4 more
doaj   +1 more source

ROLE OF SOCIAL MEDIA AS A CATALYST FOR SUSTAINABLE TOURISM DEVELOPMENT IN CALABAR METROPOLIS, NIGERIA [PDF]

Geo Journal of Tourism and Geosites
This study investigates the role of social media in tourism development in Calabar, Nigeria, emphasizing its influence on image building, destination promotion, and information dissemination.
Ukwetang John OKPA, Lilian Anwulika OKORO, Mbaze Ebock Vivian ARREY, Patrick Awok MBUM, Udeme Akaninyene UMO, Grace Michael INA H, Emmanuel Nnamdi NWOBU, Hope Amba NEJI, Okon Dorathy EFFIOM, Gabriel Tanjo ABUMBE, Christiana Aloye USHIE, Agbor Cassidy ETTA, Daniel Daniel JAMES, Ayuk Awunghe ACHU, Eja Eja IWARA *   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Is online learning effective for practice-based tourism courses? A constructive learning approach

Tourism and Hospitality Management
Purpose – The aim of this paper is to 1) measure the effectiveness of online learning in practise-based tourism courses, 2) identify the factors that influence the effectiveness of online learning and 3) propose strategies to encourage tourism students
Ilham Junaid, Marianna Sigala
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source